|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF).
|
29054571 |
2018 |
|
Dengue Fever
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a C-type lectin expressed on the plasma membrane by human immature dendritic cells, is a receptor for numerous viruses including Ebola, SARS and dengue.
|
28128492 |
2017 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FcγRIIa, CD209, VDR, TNF-α, IL-4, IL-6 and IFN-γ genes with symptom persistence.
|
26429310 |
2015 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because the -336A/G SNP (rs4804803) polymorphism in the promoter of CD209 modulates DC-SIGN expression, we investigated the putative association of this polymorphism with DENV infection and its pathogenesis.
|
24797508 |
2014 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results revealed a significantly higher frequency of 'G' allele and 'G/G' genotype of rs2287886 and A-A-G haplotype of CD209 gene in DEN compared to healthy controls [For 'G/G' genotype, P=0.0072, Odds ratio (OR) 2.43; For A-A-G haplotype, P=0.0033, OR 2].
|
23624202 |
2013 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previously the severity and outcome of dengue fever and hepatitis C (diseases caused by viruses from the family Flaviviridae) were associated with the rs4804803 single nucleotide polymorphism (SNP) located in the promoter region of the human CD209 gene.
|
22061615 |
2012 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
the rs4804803 SNP in the CD209 promoter contributed to susceptibility to dengue infection and complication of DHF.
|
21245921 |
2011 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever.
|
20359516 |
2010 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of tuberculosis and dengue fever.
|
20470843 |
2010 |
|
Dengue Fever
|
0.400 |
Biomarker
|
disease |
BEFREE |
Candidate genes that have shown statistically significant associations with DENV disease severity encode HLA molecules, cell receptors for IgG (FcGII), vitamin D and ICAM3 (DCSIGN or CD209), pathogen recognition molecules such as mannose binding lectin (MBL), blood related antigens including ABO and human platelet antigens (HPA1 and HPA2).
|
19802581 |
2010 |
|
Dengue Fever
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is evidence that infection of immature myeloid dendritic cells plays a crucial role in dengue pathogenesis and that the interaction of the viral envelope E glycoprotein with CD209/DC-SIGN is a key element for their productive infection.
|
18827881 |
2008 |
|
Dengue Fever
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have reported that the CD209 promoter single nucleotide polymorphism (SNP)-336A/G exerts an effect on CD209 expression and is associated with human susceptibility to dengue, HIV-1 and tuberculosis in humans.
|
18167547 |
2008 |
|
Dengue Fever
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever.
|
15838506 |
2005 |
|
Dengue Fever
|
0.400 |
Biomarker
|
disease |
CTD_human |
These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever.
|
15838506 |
2005 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The PubMed, SCI and Elsevier were searched up to April 18, 2015 for studies on the association of CD209 gene polymorphisms and pulmonary tuberculosis.
|
26722430 |
2015 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that CD209 rs4804803 polymorphism increased the risk of PTB in a sample of Iranian population.
|
23751770 |
2014 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we hypothesize that although carriers of CD209 -336A allele are more sensitive to infection with a Beijing strain, a combination of human CD209 -336G allele and M. tuberculosis Beijing genotype leads more frequently to the lethal outcome in pulmonary TB male patients in Russian (Caucasian) population.
|
22027159 |
2012 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Relationship between polymorphism of DC-SIGN (CD209) gene and the susceptibility to pulmonary tuberculosis in an eastern Chinese population.
|
21081145 |
2011 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene polymorphisms were studied by polymerase chain reaction based methods in HIV-1 infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls.
|
19942750 |
2009 |
|
Tuberculosis, Pulmonary
|
0.360 |
GeneticVariation
|
disease |
LHGDN |
We did not replicate an association between SNPs in the DC-SIGN promoter and TB.
|
17611589 |
2007 |
|
Tuberculosis, Pulmonary
|
0.360 |
Biomarker
|
disease |
CTD_human |
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
|
16379498 |
2006 |
|
HIV Infections
|
0.310 |
GeneticVariation
|
group |
BEFREE |
We genotyped 14 CD4 and 4 CD209 single nucleotide polymorphisms (SNPs) that were tested for association with HIV infection, HIV-2 plasma viral load (high vs. low), and CD4 T-cell count (high vs. low).
|
20924289 |
2011 |
|
HIV Infections
|
0.310 |
Biomarker
|
group |
CTD_human |
Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection.
|
15564514 |
2004 |
|
HIV Coinfection
|
0.300 |
Biomarker
|
disease |
CTD_human |
Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection.
|
15564514 |
2004 |
|
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|