Astrocytoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The values of ADC, RSIGd, EP, EI, cellular density and the expression of HIF-1α were changed with the malignant degree of astrocytoma to some extent, but not every quantitative parameter was related to the expression of HIF-1α.
|
28006727 |
2017 |
Astrocytoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers.
|
15341671 |
2004 |
Astrocytoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, our experiments elucidated that the HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced autophagy in glioblastoma and astrocytoma.
|
30569180 |
2019 |
Astrocytoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We believe that HIF-1alpha and iNOS expressions merit further investigations in order to understand the biology of astrocytic gliomas.
|
16724682 |
2006 |
Astrocytoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
HIF-1 mediated gene expression may be directly or indirectly modulated by alterations in oncogenes/tumor suppressor genes that occur during astrocytoma development, including PTEN, TP53, p16(CDKN2A), p14ARF, EGFR, and PDGFR.
|
12456339 |
2003 |
Astrocytoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since glioblastoma multiforme is the epitome of a highly aggressive tumor entity, while lower-grade astrocytomas often show a prolonged clinical course, a profound difference in the extent of hypoxic tissue areas and corresponding magnitude of HIF-1 activity may exist between these entities.
|
22825389 |
2012 |
Astrocytoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrate that increased expression and activity of LOX, BMP1 and HIF1A were positively correlated with the malignant grade of astrocytomas.
|
25790191 |
2015 |
Astrocytoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of HIF-1alpha, VEGF, Ki-67 (a proliferation-associated marker) and p53 was determined immunohistochemically in 83 adult patients with supratentorial diffuse astrocytomas.
|
15175080 |
2004 |
Astrocytoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Similarly, RGS-5 is overexpressed in highly angiogenic astrocytomas but not in hypoxia-inducible factor-1alpha (HIF-1alpha)-deficient tumors, which grow along preexisting brain capillaries without inducing neovessels.
|
15459006 |
2005 |
Astrocytoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CXCR7, CXCR4 and HIF1α mRNA expression were evaluated in 129 frozen samples of astrocytomas.
|
24970694 |
2015 |
Astrocytoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Expression of HIF-1alpha, VEGF, Ki-67 (a proliferation-associated marker) and p53 was determined immunohistochemically in 83 adult patients with supratentorial diffuse astrocytomas.
|
15175080 |
2004 |
Astrocytoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To study the putative expression patterns and clinical significance of Hsp27, we assessed the associations between Hsp27, R132H mutation of Isocitrate dehydrogenase1 (IDH1-R132H), Hypoxia-inducible factor subunit alpha (HIF-1 alpha), Carbonic anhydrase IX (CA IX), and patient prognosis in astrocytic gliomas.
|
24599602 |
2014 |