Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism.
|
12651620 |
2003 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
CTD_human |
Effect of antisense hypoxia-inducible factor 1alpha on progression, metastasis, and chemosensitivity of pancreatic cancer.
|
16628086 |
2006 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effect of small interference RNA targeting HIF-1alpha mediated by rAAV combined L: -ascorbate on pancreatic tumors in athymic mice.
|
18509748 |
2009 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the potential importance of a master regulator of the cellular adaptive response to hypoxia, hypoxia-inducible factor-1 (HIF-1), in the formation of stroma-rich microenvironments of pancreatic tumors.
|
29535824 |
2018 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF.
|
18592007 |
2008 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hypoxic conditions in the pancreatic tumor microenvironment lead to the stabilization of hypoxia-inducible factor-1 alpha (HIF-1α), which acts as the master regulator of cancer cell metabolism.
|
29330793 |
2018 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.
|
17143338 |
2006 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
LHGDN |
Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer.
|
18376310 |
2008 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In support of this finding, elevated levels of HIF-1α and SHH in pancreatic tumors were determined to be markers of decreased patient survival.
|
23633488 |
2013 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer.
|
18422749 |
2008 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the β2-AR-HIF-1α axis regulates stress-induced pancreatic tumor growth and angiogenesis.
|
23745588 |
2013 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study suggests that in hypoxic pancreatic tumors PKM2 interferes both with NF-κB/p65 and HIF-1α activation that ultimately triggers VEGF-A secretion and subsequent blood vessel formation.
|
26739387 |
2016 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer.
|
14981919 |
2004 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1alpha.
|
16552335 |
2006 |
Pancreatic Neoplasm
|
0.400 |
PosttranslationalModification
|
disease |
LHGDN |
Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells.
|
16278378 |
2005 |
Pancreatic Neoplasm
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth.
|
30676731 |
2019 |
Pancreatic Neoplasm
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of study was to discuss the correlation and regulatory mechanism of HIF-1 and miR-191 expression in pancreatic tumor.
|
25119596 |
2014 |