Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Noninfiltrating Intraductal Carcinoma
0.340 AlteredExpression disease BEFREE Clinically, LOX expression positively correlates with tumor progression and co-localization with hypoxic regions (defined by HIF-1alpha expression) in ductal carcinoma in situ and invasive ductal carcinoma primary tumors. 17685448 2008
Noninfiltrating Intraductal Carcinoma
0.340 Biomarker disease CTD_human HIF-1alpha was not expressed in benign breast tissue, whereas it was significantly expressed in DH, ADH, DCIS, and IDC (p < 0.001). 20526721 2010
Noninfiltrating Intraductal Carcinoma
0.340 AlteredExpression disease BEFREE In non-BRCA mutation-related cases the expression of the hypoxia markers in DCIS matched the expression in the invasive part in 46% or more of the cases.Although BRCA1 and BRCA2 germline mutation-related invasive breast cancers are different in many ways, the hypoxia-related proteins HIF-1α, CAIX and Glut-1 are expressed in both DCIS and invasive lesions of BRCA1 and BRCA2 mutation carriers. 23409121 2013
Noninfiltrating Intraductal Carcinoma
0.340 AlteredExpression disease BEFREE Moreover, ER(+) and HER2 protein-overexpressing DCIS showed significantly higher hypoxia-inducible factor-1α protein expression than the ER(+) and HER2 protein-nonoverexpressing tumors (P=0.016). 31192864 2019
Noninfiltrating Intraductal Carcinoma
0.340 AlteredExpression disease BEFREE HIF-1α overexpression was observed in 61.1% (11/18) of pure DCIS, in 37.9% (22/58) of DCIS-AIC and in 36.2% (21/58) of IC cases (not significant (n.s.)). 31653758 2020