|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypoxia-inducible factor 1α (HIF-1α) activity is one of the major players in hypoxia-mediated glioma progression and resistance to therapies, and therefore the focus of this study was the evaluation of HIF-1α modulation in relation to tumour response with the purpose of identifying imaging biomarkers able to document tumour response to treatment in a murine glioma model.
|
25813354 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia.
|
28427209 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypoxia-inducible factor-1α (HIF1α) contributes substantially to the stemness maintenance of GSCs and resistance of glioma to chemotherapy; thus, we investigated whether HIF1α regulates the resistance or sensitization of glioma cells to chemotherapy in different oxygen levels.
|
28801626 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analyses of receiver operating characteristic curves were done for HIF-1α to discriminate different grades of glioma.
|
29754996 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in gliomas.
|
17704802 |
2008 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Correlation of Delta-like ligand 4 (DLL4) with VEGF and HIF-1α expression in human glioma.
|
21517260 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment.
|
27090014 |
2016 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of PLD1 or PLD2 in human glioma U87 cells increased the expression of hypoxia-inducible factor-1α (HIF-1α) protein.
|
25523098 |
2014 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Exposure to hypoxia induced significant expression of CXCR4 and HIF-1alpha in glioma cells, whereas treatment with exogenous VEGF increased CXCR4 expression in HBMECs.
|
17075581 |
2006 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1alpha in human glioma in vitro and in vivo.
|
17524506 |
2007 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, expression profiling experiments in glioma cells provided detailed insight into a broad range of specific biological pathways and processes downstream of HIF-1alpha.
|
20515450 |
2010 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, HSP47 promoted glioma angiogenesis through HIF1α-VEGFR2 signaling.
|
25758142 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given its low toxicity profile, its demonstrated antitumor activity in several animal models of cancer and its potential to inhibit the HIF-1 pathway, noscapine should be considered as an antiangiogenic chemotherapy for glioma.
|
16596228 |
2006 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glioma derived isocitrate dehydrogenase-2 mutations induced up-regulation of HIF-1α and β-catenin signaling: possible impact on glioma cell metastasis and chemo-resistance.
|
22309944 |
2012 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Here we investigated the role of HIF-1alpha and HIF-2alpha in the regulation of SK1 during hypoxic stress in glioma-derived U87MG cells.
|
18055454 |
2008 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we present methods for investigating the role of HIF-1alpha in glioma growth in vivo and in vitro using RNA interference in U251, U87, and U373 glioma cells.
|
19301653 |
2009 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High levels of HOTTIP and HIF-1α were correlated with glioma metastasis and poor patient prognosis.
|
28886531 |
2017 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, HIF-1alpha stimulated whereas HIF-2alpha inhibited the hTERT promoter activity in these glioma cell lines.
|
17699105 |
2007 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-1 induced HIF-1α-TLR9 cross talk regulates inflammatory responses in glioma.
|
21756999 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, IDH mutations can also induce high levels of hypoxia-inducible factor-1α (HIF-1α) to promote glioma invasion.
|
31263678 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In Vivo Manipulation of HIF-1α Expression During Glioma Genesis.
|
29330804 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, HIF-1α-deficient-Treg mice exhibit significantly enhanced animal survival in a murine model of glioma, due to their stymied migratory capacity, explaining their reduced abundance in tumor-bearing mice.
|
30943404 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Introducing HIF-1alpha-targeted small interfering RNA (HIF-1alpha siRNA) into the glioma cell lines resulted in downregulation of HIF-1alpha expression, and significantly suppressed glioma cell migration in vitro.
|
17332917 |
2007 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, in a U87 xenograft tumor model, F2 significantly reduced intra-tumor vessel density and cell proliferation and finally retarded tumor growth, indicating that F2 may be a potential HIF-1 inhibitor and serve as one of candidates for glioma therapy.
|
29156717 |
2017 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1α.
|
23911596 |
2013 |