HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002793
Disease: Anaplasia
Anaplasia
0.350 AlteredExpression disease BEFREE In addition, in primary myofibroblast-like cells that were obtained from a patient with pulmonary fibrosis, treatment with CsA and an HIF-1α inhibitor (HIFi) decreased the expression levels of α-smooth muscle actin and fibronectin, which indicated that CsA and HIFi promote dedifferentiation of myofibroblasts. 28446589 2017
CUI: C0002793
Disease: Anaplasia
Anaplasia
0.350 AlteredExpression disease BEFREE Here, we report that hypoxia-inducible factor (HIF-1α) and cancer-associated fibroblasts (CAFs)-secreted TGF-β2 converge to activate the expression of hedgehog transcription factor GLI2 in CSCs, resulting in increased stemness/dedifferentiation and intrinsic resistance to chemotherapy. 29891662 2018
CUI: C0002793
Disease: Anaplasia
Anaplasia
0.350 Biomarker disease BEFREE High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF. 18704599 2008
CUI: C0002793
Disease: Anaplasia
Anaplasia
0.350 Biomarker disease BEFREE HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia. 28427209 2017
CUI: C0002793
Disease: Anaplasia
Anaplasia
0.350 Biomarker disease BEFREE HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels. 28801626 2017
CUI: C0002793
Disease: Anaplasia
Anaplasia
0.350 Biomarker disease CTD_human Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas. 19808899 2010