Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma
0.350 Biomarker disease BEFREE Moreover, ICI-118,551 also impaired the nuclear internalization of HIF-1α in Hemangioblastomas and hypoxic primary endothelial cells, reducing significantly the activation of HIF-target genes and halting the tumour-related angiogenic processes. 31296894 2019
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma
0.350 AlteredExpression disease BEFREE Moreover, immunohistochemical analyses of RCCs and hemangioblastomas demonstrate up-regulation of HIF-1alpha and HIF-2alpha in the tumor cells. 11114720 2000
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma
0.350 AlteredExpression disease BEFREE Whereas the development of hemangioblastomas and renal cell carcinomas has been attributed to impaired HIF-1/2alpha down-regulation by pVHL mutant proteins, the molecular defects underlying the development of pheochromocytomas are still unknown. 19228690 2009
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma
0.350 AlteredExpression disease BEFREE The VHL-HIF-1 regulated genes VEGF and CAIX are expressed in hemangioblastomas but significant HIG-2 expression is not observed. 25310734 2014
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma
0.350 Biomarker disease BEFREE HIF-1alpha was detected in tumor cell nuclei of both hemangioblastomas and CC-RCCs. 16024619 2005
CUI: C0206734
Disease: Hemangioblastoma
Hemangioblastoma
0.350 Biomarker disease CTD_human Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. 15341671 2004