Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Restoration of wild-type PTEN to glioblastoma cell lines lacking functional PTEN ablates hypoxia and IGF-1 induction of HIF-1-regulated genes.
|
10691731 |
2000 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.
|
12082608 |
2002 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings are in keeping with an important role of HIF-1alpha in the vascularization of glioblastomas and suggest that upregulation is at least partly at a transcriptional level.
|
12060345 |
2002 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion.
|
12811834 |
2003 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We examined how ionizing radiation (IR) delivered under either severe hypoxia (< 0.1% O2) or normoxia affects the expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietins 1, 2 and 4 in U87 human glioblastoma cells.
|
14712484 |
2004 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that daily administration of topotecan inhibits HIF-1alpha protein expression in U251-HRE glioblastoma xenografts.
|
15466170 |
2004 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Our findings indicated that HIF1-alpha up-regulated expression of PDGF-B in human glioblastoma cells and showed the feasibility of siRNA technology in glioblastoma cell lines.
|
16136272 |
2006 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that hypoxic up-regulation of tissue factor in glioblastoma multiforme cells depends largely on Egr-1 and is independent of HIF-1.
|
16849552 |
2006 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results indicate that in the human hypoxic A172 and U87MG glioblastoma cell lines adenosine up-regulates HIF-1alpha protein expression via the A(3) receptor subtype.
|
16682012 |
2006 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Phosphorylated KIT, its ligand stem cell factor, and the downstream signalling molecules phosphorylated Akt and mTOR were often expressed in glioblastoma cells located in the perinecrotic tumour areas that often also contained abundant HIF-1alpha.
|
17294421 |
2007 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In tumor samples, mean expression levels (LGA vs. GBM, normalized to mean expression in normal brain) were 1.71 vs. 4.57 (p<0.001) for OPN, 1.11 vs. 3.35 (p<0.001) for CA9, 2.79 vs. 5.28 (not significant, n.s.) for Epo, 1.13 vs. 2.0 (p=0.007) for VEGF and 0.97 vs. 0.97 (n.s.) for HIF-1alpha.
|
17524506 |
2007 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.
|
19587783 |
2009 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
HIF1-positive and HIF1-negative glioblastoma cells compete in vitro but cooperate in tumor growth in vivo.
|
20198320 |
2010 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, ATIA is not only a HIF-1 target that regulates mitochondrial redox pathways but also a potentially diagnostic marker and therapeutic target in human glioblastoma.
|
21658601 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma.
|
20865400 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
One feature of glioblastoma associated with poor prognosis is the degree of hypoxia and expression levels of hypoxia-inducible factor-1 α (HIF-1α).
|
21084864 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We show here that hypericin also induces enhanced degradation of hypoxia-inducible factor 1α (HIF-1α) in two human tumor cell lines, U87-MG glioblastoma and RCC-C2VHL-/- renal cell carcinoma and in the non-malignant ARPE19 retinal pigment epithelial cell line.
|
21949677 |
2011 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF) mRNA levels are increased in GBM and moderate in PA. Immunohistochemical study showed that cytoplasmic AM, VEGF and HIF-1α nuclear immunoreactivity were recorded in GBM located near large necrotic areas whereas they were not expressed by PA tumour cells.
|
21458987 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since glioblastoma multiforme is the epitome of a highly aggressive tumor entity, while lower-grade astrocytomas often show a prolonged clinical course, a profound difference in the extent of hypoxic tissue areas and corresponding magnitude of HIF-1 activity may exist between these entities.
|
22825389 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway.
|
21818118 |
2012 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Suppression of hypoxia-inducible factor 1α (HIF-1α) has been shown to sensitize glioblastoma cells to temozolomide (TMZ) treatment via down-modulation of O6-methylguanine-DNA methyltransferase (MGMT) expression.
|
23970362 |
2013 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intriguingly, the GBM sub-population enriched of cancer stem cells (CD133(+) fraction) is the primary target of the pro-differentiating effects mediated by the crosstalk between HIF-1α, Wnt, and Notch signalling.
|
23429286 |
2013 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicate that AGR2 expression is regulated by HIF-1 and plays an important role in control of glioblastoma growth and vascularity.
|
23712868 |
2013 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Considering the fact that overexpression of the HIF-1α protein is often detected in glioblastoma multiforme, melatonin may prove to be a potent therapeutic agent for this tumor.
|
23551342 |
2013 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have identified hypoxia-inducible factor 1α (HIF1α) as the downstream factor of GRIM-19 in human glioblastoma cell lines.
|
23580587 |
2013 |