|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
RGD |
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.
|
17582388 |
2007 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Relative to controls, HIF-1 expression increased fivefold in response to venous hypertension (P < 0.005), with peak expression 1 day later localized to endothelial cells in venules next to the sagittal sinus.
|
16955051 |
2006 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
To test the hypothesis that HIF-1alpha plays a role in the failing myocardium because of volume overload, an aorta-caval shunt was created for 4 weeks in adult Sprague-Dawley rats to induce volume-overload heart failure.
|
15732037 |
2005 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
To test the hypothesis that HIF-1alpha plays a role in the failing myocardium because of volume overload, an aorta-caval shunt was created for 4 weeks in adult Sprague-Dawley rats to induce volume-overload heart failure.
|
15732037 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These studies implicate HIF-1 in pathophysiologic alterations of both smooth muscle and endothelial cell biology in patients with pulmonary hypertension.
|
16373853 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization.
|
11882589 |
2002 |
|
Hypoxia-Ischemia, Brain
|
0.530 |
Biomarker
|
disease |
BEFREE |
HIF1α Signaling in the Endogenous Protective Responses after Neonatal Brain Hypoxia-Ischemia.
|
30836371 |
2019 |
|
Hypoxia-Ischemia, Brain
|
0.530 |
Biomarker
|
disease |
BEFREE |
BACKGROUND HIF-1α plays an important role in hypoxia-ischemia brain damage.
|
29724989 |
2018 |
|
Hypoxia-Ischemia, Brain
|
0.530 |
Biomarker
|
disease |
CTD_human |
Preconditioning and post-treatment with cobalt chloride in rat model of perinatal hypoxic-ischemic encephalopathy.
|
23694759 |
2014 |
|
Hypoxia-Ischemia, Brain
|
0.530 |
Biomarker
|
disease |
BEFREE |
Targeting hypoxia inducible factor-1α: a novel mechanism of ginsenoside Rg1 for brain repair after hypoxia/ischemia brain damage.
|
20874696 |
2011 |
|
Hypoxia-Ischemia, Brain
|
0.530 |
Therapeutic
|
disease |
RGD |
[Effect of Shenmai injection on expression of hypoxia-inducible factor-1alpha in hypoxic-ischemic brain damage: experiment with rats].
|
19595151 |
2009 |
|
Hypoxia-Ischemia, Brain
|
0.530 |
Biomarker
|
disease |
RGD |
The requirement of extracellular signal-related protein kinase pathway in the activation of hypoxia inducible factor 1 alpha in the developing rat brain after hypoxia-ischemia.
|
18210138 |
2008 |
|
Brain Ischemia
|
0.510 |
AlteredExpression
|
disease |
BEFREE |
We investigated the relationship between Ex-4 and HIF-1α by examining Ex-4-induced changes in HIF-1α expression in the gerbil hippocampus following global brain ischemia (in vivo) and in neuroblastoma cells (SH-SY5Y) and cortical primary neurons (in vitro).
|
24201448 |
2014 |
|
Brain Ischemia
|
0.510 |
Biomarker
|
disease |
CTD_human |
Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha.
|
19429140 |
2009 |
|
Brain Ischemia
|
0.510 |
Therapeutic
|
disease |
RGD |
Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin.
|
18369388 |
2008 |
|
Brain Ischemia
|
0.510 |
Biomarker
|
disease |
RGD |
Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia.
|
17101276 |
2007 |
|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol.
|
22050707 |
2012 |
|
Pulmonary Hypertension
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells.
|
20110409 |
2010 |
|
Myocardial Reperfusion Injury
|
0.500 |
Therapeutic
|
phenotype |
RGD |
[Protective effects of hypoxia-inducible factor-1 alpha on myocardial ischemia/reperfusion injury in rat and the role of protein kinase C in signal pathway].
|
20170615 |
2010 |
|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
RGD |
Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation.
|
19727523 |
2009 |
|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart.
|
18549825 |
2008 |
|
Pulmonary Hypertension
|
0.500 |
Biomarker
|
phenotype |
RGD |
Taken together, our results suggest that changes in HIF-1alpha and TGF-beta1 expression after hypoxia play an important role in hypoxia-induced pulmonary hypertension of rats.
|
17213961 |
2007 |
|
Pulmonary Hypertension
|
0.500 |
Biomarker
|
phenotype |
RGD |
Our study found that HIF-1alpha, HIF-2alpha and HIF-3alpha may not only confer different target genes, but also play key pathogenetic roles in hypoxic-induced pulmonary hypertension.
|
16215633 |
2005 |
|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
RGD |
Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1.
|
12189448 |
2002 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, pigment epithelium-derived factor (PEDF), an endogenous angiogenesis inhibitor, could inhibit both endothelial cell-derived and tumor cell-derived angiogenesis by down-regulating HIF-1α in breast cancer.
|
31705798 |
2020 |