HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.070 AlteredExpression disease BEFREE HIF-1α positive expression was significantly associated with vascular invasion (P = 0.002), TNM stage (P = 0.005), HBV infection (P = 0.005), tumor size (P = 0.025) and portal vein tumor thrombus (P = 0.001) in HCC with liver cirrhosis. 30274686 2018
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.070 Biomarker disease BEFREE A growing number of studies suggest that the hepatitis B virus X protein (HBx) enhances the protein stability of the hypoxia-inducible factor-1α (HIF-1α). 26647960 2016
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.070 Biomarker disease BEFREE To exclude the potential influence of HBV infection in the association between HIF-1a and HBV-related LC, a comparison between the LC patients and HBV infected patients was also conducted, but a similar insignificant result was found. 25824382 2015
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.070 GeneticVariation disease BEFREE Two polymorphisms in the HIF-1a gene (rs11549465 and rs115494657" genes_norm="3091">rs115494657) were examined in 157 hepatitis B virus (HBV)-related HCC patients and 173 healthy controls using the polymerase chain reaction-restriction fragment length polymorphism method. 25195037 2014
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.070 AlteredExpression disease BEFREE Hepatitis B virus X protein (HBx) has been shown to increase the transcriptional activity of HIF-1. 19950233 2010
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.070 AlteredExpression disease LHGDN HIF-1alpha expression was also found to be significantly correlated with the expression of hepatitis B virus X protein (HBx), and over-expressed HBx upregulated HIF-1alpha protein expression in vitro. 18465238 2008
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.070 AlteredExpression disease LHGDN Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway. 12855680 2003