HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022116
Disease: Ischemia
Ischemia
0.030 AlteredExpression phenotype LHGDN The HIF-1alpha-positive group included a higher percentage of deceased donor organs (66.4% vs 17.1%; P = .002) and longer mean cold ischemia times (261.3 +/- 231 vs 103 +/- 40 min; P = .008) compared with the HIF-1alpha-negative group. 18790175 2008
CUI: C0022116
Disease: Ischemia
Ischemia
0.030 Biomarker phenotype LHGDN Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. 18222538 2008
CUI: C0022116
Disease: Ischemia
Ischemia
0.030 AlteredExpression phenotype LHGDN These results indicate that HIF-1 activity is necessary and sufficient for the mobilization of angiogenic cells and that HIF-1alpha gene therapy can counteract the pathological effects of aging in a mouse model of limb ischemia. 17932327 2007