Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0432283
Disease: Osteoglophonic dwarfism
Osteoglophonic dwarfism
0.040 Biomarker disease BEFREE HIF-1α participated in the protective effects of PEP on OGD-treated HCMVEC. 31257333 2019
CUI: C0432283
Disease: Osteoglophonic dwarfism
Osteoglophonic dwarfism
0.040 AlteredExpression disease BEFREE LC3-II expression was gradually increased with the duration of OGD condition and knockdown of HIF-1α resulted in decreased expression of LC3. 29724989 2018
CUI: C0432283
Disease: Osteoglophonic dwarfism
Osteoglophonic dwarfism
0.040 Biomarker disease BEFREE Moreover, Nrdp1 upregulation is accompanied by increased protein ubiquitylation and decreased protein levels of ubiquitin-specific protease 8 (USP8) in OGD-treated neurons, which led to a suppressed interaction between USP8 and HIF-1α and subsequently a reduction in HIF-1α protein accumulation in neurons under OGD conditions. 28979191 2017
CUI: C0432283
Disease: Osteoglophonic dwarfism
Osteoglophonic dwarfism
0.040 AlteredExpression disease BEFREE The results indicated that Hif-1α overexpression improved cell viability, reduced G1 phase cells accumulation, and suppressed apoptosis under OGD condition (<i>P</i><0.05). 28559999 2017