|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
As a transcriptional repressor of multiple proto-oncogenes, vertebrate MBP-1 interacts with other cellular factors to attenuate the proliferation and metastasis of lung, breast, esophageal, gastric, bone, prostrate, colorectal, and cervical cancer cells.
|
30518090 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In this study, we have examined the potential of MBP-1 as a gene therapeutic candidate in regression of breast cancer growth and metastasis in an immunocompetent mouse model.
|
19934312 |
2009 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2.
|
19846662 |
2009 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CLC/Gal-10 and MBP-1 may be useful biomarkers for differentiation of eosinophilic airway inflammation in asthma.
|
31157540 |
2019 |
|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
X chromosome-linked long noncoding RNA lnc-XLEC1 regulates c-Myc-dependent cell growth by collaborating with MBP-1 in endometrial cancer.
|
30698832 |
2019 |
|
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
X chromosome-linked long noncoding RNA lnc-XLEC1 regulates c-Myc-dependent cell growth by collaborating with MBP-1 in endometrial cancer.
|
30698832 |
2019 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we investigated the degranulation patterns, including the cellular mechanisms of major basic protein-1 (MBP-1) release, from inflammatory eosinophils in a mouse model of <i>S. mansoni</i> infection (acute phase).
|
30619361 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, at earlier time points binding and invasion assay results suggest that MBP-1 participates significantly during the first interactions with the host cell while MIP-1 becomes important once the bacteria adhere to the host epithelium.
|
26252358 |
2015 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MBP-1 functions in repressing c-myc gene expression and the results presented indicate that the loss of nuclear MBP-1 expression in a large number of IDC may be a critical step in the development and progression of breast cancer and a predictor of adverse outcome.
|
20886042 |
2010 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We have shown previously an antiproliferative effect of MBP-1 on several human cancer cells.
|
19934312 |
2009 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
MBP-1 also exerted a suppressive effect on tumor progression of other gastric cancer cells such as AGS and NUGC-3 cells.
|
19846662 |
2009 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
We have shown previously an antiproliferative effect of MBP-1 on several human cancer cells.
|
19934312 |
2009 |
|
Muscular Dystrophy, Duchenne
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this investigation, we find that the release of major basic protein (MBP) by eosinophils is a prominent feature of DMD and mdx dystrophy and that eosinophils lyse muscle cells in vitro by the release of MBP-1.
|
18430716 |
2008 |
|
Muscular Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these findings show that eosinophil-derived MBP-1 plays a significant role in regulating muscular dystrophy by attenuating the cellular immune response and promoting tissue fibrosis that can eventually contribute to increased mortality.
|
18430716 |
2008 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, the mechanism of MBP-1-mediated H1299 cell death was investigated.
|
17178888 |
2006 |
|
Cholera
|
0.010 |
Biomarker
|
disease |
BEFREE |
Various concentrations of MBP (1, 10, 100 and 1000nmol/l) and its solvent dimethyl sulfoxide (DMSO) were added to the medium for 24h followed by stimulation of some compounds such as human chorionic gonadotrophin (hCG), cholera toxin (CT), forskolin, cAMP analog 8-Br-cAMP, 22(R)-hydroxycholesterol (22R-HC) and pregnenolone.
|
16999944 |
2006 |
|
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results showed a significant regression of lung tumor growth and prolonged survival on treatment with MBP-1 compared with the control groups (saline or dl312).
|
17178888 |
2006 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine the gene therapeutic potential of MBP-1, replication-deficient recombinant adenovirus expressing MBP-1 was given intratumorally in human lung cancer xenografts in nude mice.
|
17178888 |
2006 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression.
|
16762917 |
2006 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression.
|
16762917 |
2006 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine the gene therapeutic potential of MBP-1, replication-deficient recombinant adenovirus expressing MBP-1 was given intratumorally in human lung cancer xenografts in nude mice.
|
17178888 |
2006 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To determine the gene therapeutic potential of MBP-1, replication-deficient recombinant adenovirus expressing MBP-1 was given intratumorally in human lung cancer xenografts in nude mice.
|
17178888 |
2006 |
|
PACHYONYCHIA CONGENITA 3
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fluorescence-activated cell sorter analysis suggested that PC3 cells expressing MBP-1-specific small interfering RNA accumulated during G2/M phase of the cell cycle.
|
16762917 |
2006 |
|
Prostatic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Next, we investigated the therapeutic effectiveness of MBP-1 repressor domain on prostate tumors.
|
15705866 |
2005 |