|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
A close association between psoriasis and HLA-B 13 an B 17 was found in both discordant and concordant pairs.
|
6179364 |
1982 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By comparisons of empirical risk figures for psoriasis in first-degree relatives of concordant as compared with discordant MZ probands and HLA-B 13 and/or HLA-B 17 positive MZ probands compared with MZ probands lacking these antigens, no clue to the presence of genetic heterogeneity was found.
|
6204483 |
1984 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Taken together with our recent results demonstrating linkage to HLA-B and -C, this genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny.
|
9259283 |
1997 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
By applying the transmission/disequilibrium test (TDT) and parametric linkage analysis, we found evidence for linkage of psoriasis to HLA-C, -B, -DR, and -DQ, with HLA-B and -C yielding the most-significant results.
|
9634500 |
1998 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Role of HLA-B and C alleles in development of psoriasis in patients from North India.
|
9694354 |
1998 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We also conclude that the HLA-B17 allele, which is strongly associated with psoriasis, is unlikely itself to contribute directly to psoriasis susceptibility; rather, the HLA-B locus is probably tightly linked to the PSORS1 locus.
|
9694251 |
1998 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It is conceivable that an unknown susceptibility gene, on certain HLA-B-Cw haplotypes, is responsible for the development of psoriasis.
|
15140030 |
2004 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis.
|
16297191 |
2005 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our patients with type II psoriasis represented a significant association with the HLA-B*13.
|
16532100 |
2006 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
|
17587057 |
2007 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA-B*13 allele and HLA-B*13 Cw*06, TNFa11 b4 c1 d3 e3 haplotypes showed increased frequencies (p < 0.05) in patients with type II psoriasis, which suggests susceptibility to the onset of psoriasis.
|
17101473 |
2007 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p < 0.05).
|
18381784 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p < 0.05).
|
18381784 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
|
18364390 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
|
18364390 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|
18369459 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|
18369459 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Comparison of HLA-B and HLA-C regions in psoriatic arthritis with those in psoriasis without joint involvement demonstrates significant differences, such that psoriatic arthritis cannot be viewed simply as a subset of genetically homogeneous psoriasis.
|
19232079 |
2009 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
A detailed analysis of HLA-B in both populations demonstrated that HLA-B*57 was associated with an increased risk of psoriasis and HLA-B*40 a decreased risk, independently of HLA-Cw*0602 and the C6orf10 locus, suggesting the potential pathogenic involvement of HLA-B.
|
19680446 |
2009 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |