|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
An alternative possibility is that a small number of HLA-B alleles may have a very strong impact on HIV disease outcome, dominating the contribution of other HLA alleles.
|
20660184 |
2010 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.
|
17496894 |
2007 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Furthermore, HLA-B gene frequencies in the population are those likely to be most influenced by HIV disease, consistent with the observation that B alleles evolve more rapidly than A alleles.
|
15592417 |
2004 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease.
|
16933987 |
2006 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.
|
28062682 |
2017 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Sixteen HLA-B alleles groups were associated with HIV-1 infection; seven of them (43.8%) were related to slow disease progression or reduced risk of MTCT, while six (37.5%) alleles groups were linked to a faster progression of HIV infection in children and to increased risk of MTCT.
|
30772367 |
2019 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
These data corroborate the existence of significant differences in HLA-B allele frequencies among the distinct AIDS progression profiles and further elucidate the role of HLA alleles in the outcome of HIV infections in diverse populations.
|
24718028 |
2014 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
In Zambia, ReA is associated with the HLA-B*57:03 allele, which is paradoxically also associated with slow progression of HIV infection.
|
24744085 |
2014 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown.
|
29338738 |
2018 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
They specifically demonstrate that the influence of ZNRD1 alleles on disease progression rates are attributable to HLA-A10, help clarify the relationship between the HCP5, HLA-C and HLA-B*57 alleles, and reaffirm a critical role of HLA-B*57 alleles in HIV disease.
|
18982067 |
2008 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
BEFREE |
CCR5delta32 in the context of untreated HIV disease, or HLA-B*5701 allele on the abacavir hypersensitivity reaction in the context of HAART), it is more likely that HIV disease and treatment outcomes are influenced by a multitude of interacting genotypes and phenotypes, a hypothesis that will become increasingly possible to investigate as improvements in molecular and computational technologies are made.
|
16848275 |
2006 |
|
HIV Infections
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men.
|
12964117 |
2003 |