|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma.
|
31088485 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Annexin A11, a calcium-dependent phospholipid-binding protein, was expressed in a PC cell line (CFPAC-1)-derived exosomes and in tumor tissues of patients with PC, respectively.
|
30160795 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Annexin A11, a calcium-dependent phospholipid-binding protein, was expressed in a PC cell line (CFPAC-1)-derived exosomes and in tumor tissues of patients with PC, respectively.
|
30160795 |
2019 |
|
CATARACT, ANTERIOR POLAR
|
0.010 |
Biomarker
|
disease |
BEFREE |
The rats were divided into: control (saline-treated), LPS (1 mg/kg), 12.5, 25 or 50 mg/kg captopril-treated before LPS administration (LPS+Cap12.5, LPS+Cap25 and LPS+Cap50) and Cap-treated, 50 mg/kg before saline administration (as positive control group)groups.
|
29847180 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, ANXA11 was identified as direct downstream targets of miR-16-5p in HCC cells, and mediated the functional effects of miR-16-5p and AGAP2-AS1 in HCC, resulting in AKT signaling activation.
|
31088485 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that ANXA11 participates in many cellular functions and has significant influence on ovarian, breast, liver, and colorectal cancer.
|
29306955 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression and biological functions of ANXA11 in GC are still unknown.
|
29306955 |
2018 |
|
Uveitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SNPs rs1040461 and rs61860052, in ras-related protein RAS23 (<i>RAB23</i>) and annexin A11 (<i>ANXA11</i>) genes, respectively, were associated with sarcoidosis-associated uveitis.
|
29416296 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In clinicopathological analysis, we found that increased expression of ANXA11 was significantly associated with tumor size, tumor infiltration, local lymph node metastasis, TNM staging, and vascular invasion.
|
29306955 |
2018 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression and biological functions of ANXA11 in GC are still unknown.
|
29306955 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Small interfering RNA (siRNA) silencing of ANXA11 inhibits cell proliferation, colony formation, migration, and invasion through the AKT/GSK-3β pathway.
|
29306955 |
2018 |
|
IgG4-Related Sclerosing Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease.
|
28765476 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that ANXA11 participates in many cellular functions and has significant influence on ovarian, breast, liver, and colorectal cancer.
|
29306955 |
2018 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Annexin A11 is associated with pulmonary fibrosis in African American patients with sarcoidosis.
|
28079857 |
2016 |
|
Celiac Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Primary biliary cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Juvenile arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Juvenile rheumatoid arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Variants originally associated with juvenile idiopathic arthritis (VTCN1 gene), sarcoidosis (ANXA11 gene), primary biliary cirrhosis (IL12RB2 gene) and celiac disease (LPP gene) were not associated with type 1 diabetes in our dataset.
|
23152861 |
2012 |
|
Lymphadenopathy
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Furthermore, ANXA11(*)T allele was less frequent in patients with the infiltration of lung parenchyma by comparison with those with isolated hilar lymphadenopathy (P=0.01).
|
21562576 |
2011 |
|
Recurrent tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We have previously reported that annexin A11 is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients.
|
19484149 |
2009 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, annexin A11 is directly involved in cell proliferation and cisplatin resistance of ovarian cancer.
|
19484149 |
2009 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Manipulation of annexin A11 and its associated genes may represent a novel therapeutic strategy in human ovarian cancers.
|
19484149 |
2009 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, annexin A11 is directly involved in cell proliferation and cisplatin resistance of ovarian cancer.
|
19484149 |
2009 |
|
Neural Tube Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
Among the identified VPA-responsive genes, some have been associated previously with NTDs or VPA effects [vinculin, metallothioneins 1 and 2 (Mt1, Mt2), keratin 1-18 (Krt1-18)], whereas others provide novel putative VPA targets, some of which are associated with processes relevant to neural tube formation and closure [transgelin 2 (Tagln2), thyroid hormone receptor interacting protein 6, galectin-1 (Lgals1), inhibitor of DNA binding 1 (Idb1), fatty acid synthase (Fasn), annexins A5 and A11 (Anxa5, Anxa11)], or with VPA effects or known molecular actions of VPA (Lgals1, Mt1, Mt2, Id1, Fasn, Anxa5, Anxa11, Krt1-18).
|
15345369 |
2004 |