Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE Along with demographic factors and HLA-DR-DQ, genotypes for HLA-DPB1 and 5 non-HLA loci conferring risk of both T1D and CD were analyzed. 29018046 2017
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 Biomarker disease BEFREE Within TEDDY, a nested case-control design of 248 children with CD autoimmunity (CDA) and 248 matched control children were genotyped for HLA-B, -DRB3, -DRB4, -DPA1, and -DPB1 genes, and the entire cohort was genotyped for single-nucleotide polymorphisms (SNPs) using the Illumina ImmunoChip. 26010309 2015
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 Biomarker disease CTD_human Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease. 17956852 2008
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE None of the TNF, TAP, or DPB1 alleles was found to be significantly associated with CD. 9548076 1998
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 Biomarker disease BEFREE We reasoned that if DPB1*0101 would not play a role in CD, then patients should inherit the DQ2 haplotypes randomly from a homozygous parent. 9129973 1997
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE We studied DQA1, DQB1, and DPB1 alleles in 31 Finnish families with celiac disease (CD). 8803535 1996
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE For this reason we have studied 50 adult Sardinian patients with celiac disease (CD) and 50 control healthy Sardinian individuals by RFLP analysis and by extensive oligotyping for 17 HLA-DPB1, 8-DQB1 and 9-DQA1 alleles, and established their -DPB1 alleles and -DQB1 -DQA1 genotypes. 8590546 1995
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE The linkage of the DPB1*0101 allele with the DQ locus and the observation that the DP but not the DQ association appears to be ethnically dependent strongly support a secondary role of DP molecules in celiac disease susceptibility. 1361687 1992
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 Biomarker disease BEFREE Furthermore, no association between HLA-DP and celiac disease was found in this study. 1356956 1992
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE Polymorphisms of the HLA-DP region loci have been shown to associate with autoimmune diseases which share immunological features with IgAN; coeliac disease (CD) and dermatitis herpetiformis (DH). 1314989 1992
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE A family study confirms that the HLA-DP associations with celiac disease are the result of an extended HLA-DR3 haplotype. 1676703 1991
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE Further, they indicate that a specific DQ molecule, when present in combination with the product of one of several different DPB1 alleles, may contribute to susceptibility to the intestinal lesion, which is common to dermatitis herpetiformis and celiac disease. 1919044 1991
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE We therefore conclude that a gene(s) in the HLA-DP region predisposes to coeliac disease independently of the HLA-DR/DQ regions. 1974234 1990
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE Thus, the observed increase of the DPA1*0201 and DPB1*0101 alleles among CD patients seems mainly to be caused by linkage disequilibrium to the CD-associated DQ alleles. 1980918 1990
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE A combination of a particular HLA-DP beta allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease. 2498667 1989
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE Furthermore, the increased frequency of the 4.0-kilobase Rsa I DP B gene restriction fragment length polymorphism in celiac disease can be accounted for by the overrepresentation in disease of the alleles DPB1 and DPB3. 2788285 1989
CUI: C0007570
Disease: Celiac Disease
Celiac Disease
0.400 GeneticVariation disease BEFREE Thus, celiac disease is associated with a subset of HLA-DR3, -DQw2 haplotypes characterized by HLA-DP alpha- and beta-chain gene RFLPs. 2893373 1988