|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of RA was associated with having any child compatible at HLA-B (OR 1.9; 1.2-3.1), DPB1 (OR 1.8; 1.2-2.6) or DQB1 (OR 1.8; 1.2-2.7).
|
30635658 |
2020 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Strong association was observed between SNP rs9277535 in HLA-DP and RA susceptibility (allele frequency distribution: OR = 1.409, 95%CI = 1.121-1.773, P = 0.004).
|
29476350 |
2018 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65-0.94).
|
30235330 |
2018 |
|
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This meta-analysis demonstrates that high frequency expression of DPB1*0401 and *0601 are significantly associated with susceptibility to RA, it may be a risk factor for occurrence of RA.
|
29425827 |
2018 |
|
cervical cancer
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019).
|
30009173 |
2018 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We tested the association between having any child with alleles encoding amino acids (AAs) associated with RA including the 'shared epitope' (SE) and DERAA AA sequences at positions 70-74; AA valine, lysine and alanine at positions 11, 71 and 74 of HLA-DRB1; aspartic acid at position 9 of HLA-B and phenylalanine at position 9 of DPB1.
|
28391248 |
2017 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population.
|
28119119 |
2017 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association of two single nucleotide polymorphism (SNPs), one in the HLA-DPB1 (rs9277535) and one in the HLA-DQB2 (rs7453920), with chronic hepatitis B infection in a southern Brazilian sample.
|
28613373 |
2017 |
|
cervical cancer
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association was detected between HLA-DPB1 alleles and cervical cancer risk in the Japanese population.
|
27193219 |
2016 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A weighted genetic risk score (wGRS) was created using 45 RA non-human leucocyte antigen (HLA) susceptibility loci, imputed amino acids at HLA-DRB1 (11, 71 and 74), HLA-DPB1 (position 9) HLA-B (position 9) and gender.
|
24092415 |
2015 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals.
|
26449183 |
2015 |
|
cervical cancer
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether polymorphisms in the HLA-DPB1 gene were associated with cervical cancer risk in a Taiwanese population.
|
26031576 |
2015 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of HLA-DP polymorphisms with response to peginterferon (PEG-IFN) in Caucasian chronic hepatitis B (CHB) patients.
|
25109699 |
2014 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.
|
24940741 |
2014 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB).
|
24465836 |
2014 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Some variants of the HLA-DP locus (HLA-DPA1 A allele and HLA-DPB1) protect against progression of chronic hepatitis B infection.
|
24654629 |
2014 |
|
Hepatitis B, Chronic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
HLA-DP and γ-interferon receptor-2 gene variants and their association with viral hepatitis activity in chronic hepatitis B infection.
|
23980639 |
2014 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, whether there exists an association between HLA-DP variants and the progression of CHBVI remains to be determined.
|
24846544 |
2014 |
|
cervical cancer
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study provides the first systematic investigation of the association of genetic variants in the HLA-DP region with cervical cancer susceptibility and provides further insight into the contribution of polymorphisms in the HLA-DP region to risk of cervical cancer.
|
24743517 |
2014 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DPB1*05:01 was the only allele associated with the presence of both anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese RA and SLE patients.
|
23320107 |
2013 |
|
Hepatitis B, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.
|
23449268 |
2013 |
|
cervical cancer
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75).
|
23817570 |
2013 |
|
cervical cancer
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females.
|
23428460 |
2013 |