|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate a possible correlation between the HLA-DQA1 and HLA-DQB1 genetic markers and clinical features of celiac disease.
|
12050583 |
2002 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individuals homozygous for DQ2 or heterozygous for DQA1*05-DQB1*02/DQA1*0201-DQB1*02 were found to be at five-fold increased risk for development of coeliac disease (P<10(-8)).
|
15014431 |
2004 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Less frequently, CD occurs in individuals positive for the DQ2.x heterodimers (DQA1≠*05 and DQB1*02) and very rarely in patients negative for these DQ predisposing markers.
|
23050549 |
2012 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene.
|
2909659 |
1989 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
celiac disease is associated with the HLA class II alleles: DQA1*05-DQB1*02 and DQB1*0302.
|
24274444 |
2013 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DQA1*0501 and DQB1*0201 alleles (hereafter DQ2) confer genetic susceptibility to celiac disease (CD).
|
9129973 |
1997 |
|
Celiac Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrated that HLA DQA1*05 and DQB1*02 gene expression is much higher than expression of non-CD-associated genes.
|
27083396 |
2016 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents.
|
12590980 |
2003 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic investigation regarding all three patients revealed the existence of HLA DQ A1*0501 allele associated with susceptibility to coeliac disease.
|
11208478 |
2001 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DQA1*0101 allele appears significantly in DS-CD + patients and deserves to be searched for in a larger sample to assess its meaning in the DS-CD association.
|
8890082 |
1996 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We propose the use of the DQ-CD Typing kit that allows identification of the HLA class II alleles (DQA1*0201,*03,*05, DQB1*02,*0302, DRB1*03,*04,*07) selected to be informative in the CD risk evaluation and of a second kit, namely DQ-CD Zygosis, for DQB1*02 homozygosity determination.
|
18076355 |
2008 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The vast majority of these T cells recognize gluten peptides when presented by HLA-DQ2 (DQA1*05/DQB1*02), a molecule which immunogenetic studies have identified as conferring susceptibility to CD.
|
11673490 |
2001 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
However other genetic factors are probably relevant, since about 10% of the patients with DH and CD lack the DQA1*0501/B1*0201 heterodimer while the majority of individuals presenting this genotype and also being exposed to gluten diets did not suffer from these diseases.
|
1627534 |
1992 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Both HLA alleles DQA1*05 and DQB1*02 are associated with a greatly increased risk of CD, although the latter has the greater effect.
|
17919990 |
2007 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A gene dosage effect of the DQA1*0501/DQB1*0201 allelic combination influences the clinical heterogeneity of celiac disease.
|
7928444 |
1994 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4.
|
11862400 |
2002 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk.
|
26010309 |
2015 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For the development of classic gluten-sensitive CD a certain HLA haplotype involving the loci DQA1* and DQB1* and encoding two different HLA DQ heterodimers is the prerequisite.
|
23609110 |
2013 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
High-resolution, sequence-specific oligonucleotide probe typing with 35 DQA1-specific and 37 DQB1-specific probes of DNA from more than 10,000 subjects was used to stratify risk of CD in an at-risk U.S. population.
|
19500688 |
2009 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, these DP alleles were in linkage disequilibrium with CD-associated DQ alleles in the normal population, and the difference in frequency of these DP alleles was no longer significant when CD patients and healthy controls carrying the CD-associated DQA1*0501 and DQB1*0201 alleles were compared.
|
1980918 |
1990 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of CD patients, 92% (50% DR3 and 42% DR5,7) compared to 18% of the controls carry both DQA1*0501 and DQB1*0201 alleles, so that the combination confers an RR of 52, higher than both the risks of the single alleles (DQA1*0501 RR = 19, DQB1*0201 RR = 30), confirming the primary role of the dimer in determining genetic predisposition to CD both in DR3 and in DR5,7 subjects.
|
1563982 |
1992 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
An association with a 15 base-pair deletion in exon 12 of PRSS16 was found on the DRB1*03-DQA1*0501-DQB1*0201 haplotype for both T1D and CD, but it could not explain the more pronounced disease associations observed at marker D6S2223.
|
17584581 |
2007 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic predisposition to celiac disease (CD) is determined primarily by the human leukocyte antigen (HLA) genes (CELIAC1 region; 6p21), although many loci are involved in disease susceptibility.
|
17767555 |
2007 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the HLA DRB1, DQB1 and DQA1 polymorphism in Tunisian children with typical form of coeliac disease (CD) in comparison with those from mass screening (atypical and silent CD).
|
19474744 |
2009 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the association with CD became stronger when B*08(B*08-DQA*0501-DQB1*0201-DRB1*0301, P = 5.07 x 10(-12)) was present in the DRB1*0301-DQB1*0201-DQA1*0501 (P = 5.00 x 10(-10)) extended haplotype.
|
20492597 |
2010 |