|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In contrast with a previous investigation of Norwegian MS patients, no association of MS with glutamine at position 34 of the HLA-DQ alpha chain or with defined sequences of the HLA-DQB1 gene was found.
|
1359021 |
1992 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis.
|
2001977 |
1991 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To verify whether HLA-DQA and HLA-DQB genes differed between unrelated (MSU) and related (MSR) patients, and whether relapsing-remitting and chronic progressive forms of MS are immunogenetically distinct entities.
|
8442703 |
1993 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interactions between both HLA-DMB and the HLA-DRA promoter and other reported MS susceptibility loci were examined (TCRBV polymorphisms, HLA-DQA1 and HLA-DQB1).
|
10527398 |
1999 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although no significant differences were found between the patients and controls for the DRB1 and DQA1 alleles, the HLA-DQB1*0602 allele was positively associated with multiple sclerosis (45.0% vs. 17.0%, Pc=0.024, RR=3.31).
|
10599893 |
1999 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).
|
12590979 |
2003 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans.
|
14669136 |
2004 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is striking that the common DQ6 allele HLA-DQB1(*)0602 is found in linkage disequilibrium with HLA-DRB1(*)1501, and this combination defines the HLA genotype associated with the development of multiple sclerosis.
|
14735143 |
2004 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain.
|
15083289 |
2004 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The frequencies of HLA-DRB1 * 1501, HLA-DRB5 * 0101, HLA-DRB3 * 0301, and HLA-DQB1* 0602 were not as high in Korean children with multiple sclerosis as in western children.
|
15201511 |
2004 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref.1).
|
16186814 |
2005 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
HLA-DR15 haplotype and multiple sclerosis: a HuGE review.
|
17329717 |
2007 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami.
|
17389012 |
2007 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients.
|
17489940 |
2007 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk.
|
17845076 |
2007 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA haplogroups and HLA class II association.
|
18312478 |
2008 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk.
|
18433881 |
2008 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk.
|
18606010 |
2008 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*15 and HLA-DQB1*0602, nearly always located together on a small ancestral chromosome segment, are strongly MS-associated.
|
19380721 |
2009 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This new humanized model of MS further implicates autoimmunity against MOBP in MS pathogenesis, provides the first evidence of pathogenic HLA-DQ-associated anti-myelin autoimmunity, and is the first to offer a rationale for HLA-DQB1*0602 association with MS.
|
19648275 |
2009 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p<0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p<0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p<0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p=0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p<0.001) alleles were found to be risk factors for MS.
|
19896562 |
2010 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Opposing association signals with MS were observed for alleles composing the DRB1*0301-DQB1*0201 haplotype: positive association of the HLA-DRB1*0301 allele in Muslims (P(Bonferroni)=0.004, odds ratio (OR)=3.07), and negative association in Christian Arabs (P(Bonferroni)=0.01, OR=0.12), with similar results obtained for HLA-DQB1*0201.
|
20463743 |
2010 |
|
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of HLA-DQB1*0402 allele was increased in NMO (p after Bonferroni correction, cp < 0.035) and the HLA-DRB1*15 and DQB1*06 alleles were increased in MS (cp < 0.0027, cp < 0.01), compared to controls.
|
21908482 |
2012 |
|
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The HLA-DRB1*1501- and HLA-DQB1*0602-Tg mice (MHC-II(-/-)), and control non-HLA-DR15-relevant-Tg mice were immunized with a set of overlapping PLP peptides or with recombinant soluble PLP for induction of "humanized" MS-like disease, as well as for ex-vivo analysis of immunogenic/immunodominant HLA-restricted T-cell epitopes and associated cytokine secretion profile.
|
22316121 |
2012 |