|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate a possible correlation between the HLA-DQA1 and HLA-DQB1 genetic markers and clinical features of celiac disease.
|
12050583 |
2002 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Moreover, individuals with at least 1 HLA-DQB1*02 allele tend to have a more expressed clinical and histological form of celiac disease.
|
18728523 |
2008 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have recently reported that the susceptibility to develop celiac disease (CD) seems to be primarily associated to a particular combination of an HLA-DQA1 (DQA1*0501) and an HLA-DQB1 (DQB1*0201) allele: i.e., a particular DQ alpha/beta heterodimer.
|
1980918 |
1990 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results show that HLA-DRB1*03, HLA-DRB1*07, and HLA-DQB1*02 alleles conferred susceptibility to CD in Brazilian patients.
|
11045836 |
2000 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We studied nine consecutive DQ2-negative celiacs [from a group of 186 consecutive celiac disease (CD) patients] for the presence of the HLA-DQB1, DRB1, and DRBx alleles.
|
11061289 |
2000 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study we analysed this population to evaluate the degree of association with CD of the haplotypes and genotypes at the main HLA-DQB1 and DQA1 disease loci.
|
11929591 |
2001 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As expected, all CD patients had at least one of the CD-associated alleles, and the highest CD risk was indicated by the presence of the HLA-DQ2.5 heterodimer (HLA-DQA1*05-DQB1*02) with HLA-DQB1*02 in homozygosity.
|
25413104 |
2014 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic predisposition to celiac disease (CD) is determined primarily by the human leukocyte antigen (HLA) genes (CELIAC1 region; 6p21), although many loci are involved in disease susceptibility.
|
17767555 |
2007 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing.
|
23050549 |
2012 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic predisposition to coeliac disease (CD) is determined primarily by alleles at the HLA-DQB locus, and evidence exists implicating other major histocompatibility complex-linked genes (6p21) and the CTLA4 locus on chromosome 2q33.
|
15713213 |
2005 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, multivariate analysis demonstrated that patients with potential CD have a higher frequency of both HLA-DQB1*0302 and HLA-DQB1*0603 alleles and a reduced frequency of DQB1*02 homozygosity compared with patients with uncomplicated and complicated CD.
|
21694611 |
2012 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study shows a significant gene dose effect in terms of tTGA level at diagnosis, but no significant association between HLA-DQB1*02 allele dose and the clinical outcomes in CD.
|
30779476 |
2019 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, individuals with at least 1 HLA-DQB1*02 allele tend to have a more expressed clinical and histological form of celiac disease.
|
18728523 |
2008 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DQA1 and HLA-DQB1 Alleles, Conferring Susceptibility to Celiac Disease and Type 1 Diabetes, are More Expressed Than Non-Predisposing Alleles and are Coordinately Regulated.
|
31331105 |
2019 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
LHGDN |
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.
|
16878175 |
2006 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain.
|
15120190 |
2004 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine the contribution of HLA-DQA1* and HLA-DQB1* genes to the risk of coeliac disease (CD) in a cohort of children with type 1 diabetes mellitus (T1DM) from northern Italy.
|
15174785 |
2004 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism within the HLA-DQB1*02 promoter associated with susceptibility to coeliac disease.
|
9587738 |
1998 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the non-CD family history group, an association between delayed disease onset and HLA-DQ8 carriage was observed (p < 0.001), besides an influence of HLA-DQB1*02 gene dosage on clinical presentation and severity of histological damage (after adjusting for age and sex, p = 0.05 and p = 0.02, respectively) and a trend towards presence of specific antibodies (p = 0.09).
|
31196071 |
2019 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The proportion of clinically undetected celiac disease may be particularly high among 3-year-old children with HLA-DQB1*02 and DQB1*0302 in Sweden, where these 2 HLA-risk alleles frequently occur.
|
19915493 |
2010 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, patients with type 1 diabetes who had the HLA-DQB 1*02 allele and, therefore, a higher risk for celiac disease (CD) absorbed significantly more mannitol (mean + 95% CI): 17.7% (15.2-20.2) than did those negative for this allele: 12.3% (8.2-16.4), p = 0.04.
|
12515291 |
2002 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the risk of CD in children with type 1 diabetes is significantly modified both by the presence of HLA-DQB1*02-DQA1*05 and by a variant of another gene within the major histocompatibility complex, the TNF -308A.
|
16567828 |
2006 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Indeed, no differences have been found in CD risk between DQ2/β2 and DQ2/DQ2, as well as between DQ8/β2 and DQ2/DQ8, and between β2/DQX and DQ2/X.ConclusionThe HLA-DQB1*02:01 allele is present in more than 90% CD children.
|
29244800 |
2018 |