|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Narcolepsy (hypocretin deficiency), a sleep disorder characterized by sleepiness, cataplexy and rapid eye movement (REM) sleep abnormalities, is tightly associated with HLA-DRB1*1501 (M17378) and HLA-DQB1*0602 (M20432).
|
18820697 |
2008 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This comprehensive genetic study sought to assess variations in CHKB and CPT1B susceptibility genes and HLA-DQB1*06:02 allele status in Turkish patients with narcolepsy and healthy persons.
|
24571861 |
2014 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of the HLA-DQB1*0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit in São Paulo.
|
19506770 |
2009 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy.
|
26123389 |
2015 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Passive smoking may be a risk factor for narcolepsy in subjects with HLA DQB1*0602.
|
19039244 |
2009 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Carrying HLA-DQB1*06:02 was significantly associated with narcolepsy, odds ratio (OR) 39.4 [95% confidence interval (CI) 11.3, 137], p = 7.9 × 10<sup>-9</sup>.
|
30711515 |
2019 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population.
|
27081540 |
2015 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
The association of narcolepsy with HLA-DQB1*0602 is established in Japanese, African-Americans, European, and North American Caucasians.
|
17207713 |
2007 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency.
|
25197808 |
2014 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Biological markers of narcolepsy with cataplexy (classical narcolepsy) include sleep-onset REM periods (SOREM) on multiple sleep latency tests (MSLT), HLA-DQB1*0602 positivity, low levels of cerebrospinal fluid (CSF) hypocretin-1 (orexin A), increased body mass index (BMI), and high levels of CSF leptin.
|
14592354 |
2003 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. A systematic meta-analysis.
|
30321823 |
2018 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy.
|
28658402 |
2017 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
The tight co-segregation of HLA DQB1*0602 and narcolepsy spectrum disorders might suggest that HLA typing, especially DQB1*0602, at least partly confer the familial risk of narcolepsy.
|
17682655 |
2007 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our study aimed to determine the prevalence of HLA-DQB1*0602 allele in Iranian patients with narcolepsy and assess its predictive parameters for diagnosing narcolepsy.
|
29149785 |
2017 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Polygenic risks in narcolepsy were estimated to explain 58.1% (P<sub>HLA-DQB1*06:02</sub>=2.30 × 10<sup>-48</sup>, P<sub>whole genome without HLA-DQB1*06:02</sub>=6.73 × 10<sup>-2</sup>) including HLA-DQB1*06:02 effects and 1.3% (P<sub>whole genome without HLA-DQB1*06:02</sub>=2.43 × 10<sup>-2</sup>) excluding HLA-DQB1*06:02 effects.
|
27305985 |
2016 |
|
Narcolepsy
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The high frequency of HLA-DQB1*0602, low frequency of HLA-DQB1*0601 and low hypocretin levels in cataplexy-positive groups suggest that cataplexy-positive narcolepsy might be an etiologically different disease entity from the cataplexy-negative.
|
17297265 |
2007 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
We investigated the association between birth order and narcolepsy risk in a population-based case-control study in which all study subjects were HLA-DQB1*0602 positive.
|
22281000 |
2012 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
LHGDN |
[Diagnosis of childhood narcolepsy and significance of HLA in its diagnosis].
|
15157381 |
2004 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
For narcolepsy with HLA-DQB1 *0602, prevalence was 15.3 (95% CI: 12.8-17.9).
|
19013100 |
2009 |
|
Narcolepsy
|
0.800 |
SusceptibilityMutation
|
disease |
ORPHANET |
Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested.
|
18706091 |
2008 |