Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease BEFREE A family history for both type 1 and type 2 diabetes was associated with higher prevalence of GAD antibodies and HLA-DQB1 risk genotypes than a family history of type 2 diabetes only, and was associated with earlier and more severe development of insulin deficiency, which was only partially explained by GAD antibodies and HLA. 23157220 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease LHGDN HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients. 18279373 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease BEFREE Our data suggested that HLA-DQB1 alleles of all three risk classes, INS variable number of tandem repeat (VNTR) I/I and CTLA-4 +49 GG or AG genotypes, were independent risk factors for developing LADA and could be used as a diagnostic tool to discriminate between LADA and T2D. 17257313 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.190 Biomarker disease BEFREE However, in patients without islet antibodies, HLA-DQB1 genotyping together with C-peptide measurement may be of value in differentiating between idiopathic type 1 diabetes and type 2 diabetes. 16783473 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease BEFREE To study whether the TNF alpha gene could be such a modifying gene, we studied TNF alpha promoter polymorphisms (G-->A substitution at positions -308 and -238) in relation to HLA-DQB1 genotypes in type 2 patients from mixed type 1/2 families or common type 2 diabetes families as well as in patients with adult-onset type 1 diabetes and control subjects. 12788886 2003
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease LHGDN To study whether the TNF alpha gene could be such a modifying gene, we studied TNF alpha promoter polymorphisms (G-->A substitution at positions -308 and -238) in relation to HLA-DQB1 genotypes in type 2 patients from mixed type 1/2 families or common type 2 diabetes families as well as in patients with adult-onset type 1 diabetes and control subjects. 12788886 2003
Diabetes Mellitus, Non-Insulin-Dependent
0.190 Biomarker disease BEFREE In this study, we investigated the occurrence of T1D in 253 Lebanese Caucasian patients, in relation to HLA-DQB1*0201, HLA-DQB1*0302, HLA-DQB1*0602, gender, and early exposure to cow's milk, as well as to family history of T1D and type-2 diabetes (T2D). 12107223 2002
Diabetes Mellitus, Non-Insulin-Dependent
0.190 Biomarker disease BEFREE We present the case of a well characterised M.O.D.Y. type 2 diabetes family in which one of the children associated beta cell autoimmunity and a HLA DQB1 at risk for immune-mediated type 1 diabetes mellitus. 11240447 2001
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease BEFREE Furthermore, we studied the frequency of GAD antibodies (GADabs), HLA-DQB1 risk genotypes, and the presence of coronary heart disease (CHD) according to family history in unrelated patients with type 2 diabetes from 787 families (148 FH-, 546 FH+(TYPE2) and 93 FH+(MIXED)). 10834414 2000
Diabetes Mellitus, Non-Insulin-Dependent
0.190 GeneticVariation disease BEFREE A missense mutation of R272H (replacement of Arg by His in codon 272) in the DNA binding domain of HNF-1 alpha was found in a subject who developed IDDM 1 year after diagnosis of NIDDM at 8 years of age. 9313763 1997