Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 Biomarker disease BEFREE Association of HLA-DQB1*03:01 and DRB1*11:01 with spontaneous clearance of hepatitis C virus in Chinese Li ethnicity, an ethnic group genetically distinct from Chinese Han ethnicity and infected with unique HCV subtype. 31254396 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 Biomarker disease BEFREE After identifying single-nucleotide polymorphism clusters located in the human leukocyte antigen (HLA) region which were potentially associated with HCC, HLA-DQB1 genotyping was performed to analyze 994 anti-HCV seropositives collected in the period 1991-2013 in a community-based cohort for evaluating long-term predictability of HLA variants for identifying the risk of HCC. 28921602 2018
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 Biomarker disease BEFREE HLA-DQB1 (p = 1.76⁎10(-5)) and IL-6 (p = 0.0007) genes were significantly associated with spontaneous HCV clearance. 27340680 2016
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 GeneticVariation disease BEFREE Our findings suggest that a common amino acid substitution in HLA-DQB1 affects susceptibility to chronic infection with HCV in the Japanese population and may not be independent of the IFNL4 genotype. 24376798 2013
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 GeneticVariation disease BEFREE There was no significant difference between the phenotypic frequencies of HLA-DRB1 (17.3 vs 14.0%) and HLA-DQB1 alleles in responder and non-responder HCV patients. 18925312 2008
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 GeneticVariation disease BEFREE DNA obtained from 141 Spanish patients with HCV infection (48 with alanine aminotransferase levels in the range considered to be normal, 47 with liver cirrhosis, and 46 with hepatocellular carcinomas [HCCs]) and from 116 control subjects were typed for HLA-B, HLA-DRB1, and HLA-DQB1 alleles, as well as for major histocompatibility complex class I chain-related gene A (MICA) transmembrane polymorphism. 14999597 2004
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 GeneticVariation disease LHGDN Hepatitis C virus-related hepatocellular carcinoma and B-cell lymphoma patients show a different profile of major histocompatibility complex class II alleles. 15556690 2004
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 GeneticVariation disease BEFREE Our results show that the presence of HLA-DRB1*11 and HLA-DQB1*03 alleles is associated with a reduced risk for the development of HCV induced end stage liver disease. 11302974 2001
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.090 GeneticVariation disease BEFREE Self-limiting HCV infection was associated with HLA-DRB1*1101 (odds ratio 2.14 [95% CI 1.11-4.12]; p=0.013) and HLA-DQB1*0301 (2.22 [1.24-3.96], p=0.004). 10609818 2000