Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus. 16320082 2005
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Besides the well recognized association of HLA-DRB1 and DQB1 alleles with type 1 diabetes mellitus (T1D), linkage studies have identified a gene region close to the non-classical class I HLA-G gene as an independent susceptibility marker. 26883941 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Besides the acknowledged correlation between the HLA-A*02 and HLA-B*15 alleles (as well as low birth weight) and type I diabetes and between the HLA-B*38 and HLA-DRB1*13 alleles (as well as high birth weight) and several autoimmune diseases, we cannot predict if our babies, healthy at birth, will suffer from these pathologies during life. 19500315 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The main genetic predisposition to type 1 diabetes (T1D) is known to be conferred by the HLA-DRB1, -DQA1 and -DQB1 genes in the major histocompatibility complex (MHC). 18987644 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In conclusion, of the five subtypes of DR2, only one, the DRB1*1501, DRB5*0101, DQB1*0602-DQA1*0102 haplotype, was negatively associated with IDDM. 7817375 1994
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The distribution of DR4 haplotypes in Sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci. 7499178 1995
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Previous studies have shown that the risk for LADA, similarly to type 1 diabetes mellitus (T1DM), is increased in subjects carrying the HLA-DRB1*03-DQA1*0501-DQB1*0201 and/or HLA-DRB1*04-DQA1*0301-DQB1*0302 haplotypes. 12021137 2002
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Significant differences are detected between IDDM and control groups in the frequencies of DRB1*0402 DQA1*03 DQB1*0302 (28.1% vs. 5.2%, p < 0.0001, OR: 7.1) and DRB1*0301 DQA1*0501 DQB1*02 (57% vs. 18.1%, p < 0.0001, OR: 6.1). 10689119 2000
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE This included: Norwegian subjects with Celiac disease and the HLA DRB1*0301, DQA1*05011, DQB1*02 haplotype; Japanese subjects with Type 1 (insulin-dependent) Diabetes Mellitus and the HLA DRB1*0405, DQA1*0302, DQB1*0401 haplotype; and French patients with corticosensitive Idiopathic Nephrotic Syndrome and the HLA DRB1*0701, DQA1*0201, DQB1*0202 haplotype. 8560448 1995
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE We have identified a new susceptibility locus within the MHC with a modest contribution to T1D (OR=1.93; CI: 1.52-2.44; P=10(-8)) that is independent of HLA-DRB1 locus. 19458622 2009
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Of these 10 SNPs, 5 are located between DQB1 and DRB1, confirming the known association with the DR3 and DR4 haplotypes whereas two additional SNPs also reproduced known associations of T1D with DOB and LTA. 12706109 2003
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Family analysis revealed involvement of multiple DR3+ve haplotypes with T1DM in North Indian children with A26-B8-DRB1*03 (25% vs 3.5%, chi2=16.9, p=3.96E-05) and Ax-B50-DRB1*03 (25% vs 0.7%, chi2=44.7, p=9.88E-11) being the most frequent haplotypes encountered among patients. 14700595 2004
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children). 27623983 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. 8226139 1993
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The objective of this study was to characterize the peptide-binding motif of the major histocompatibility complex (MHC) class II HLA-DR8 molecule included in the type 1 diabetes-associated haplotype DRB1(*)0801-DQA1(*)0401/DQB1(*)0402 (DR8-DQ4), and compare it with that of other diabetes-associated MHC class II alleles; DR8-bound peptides were eluted from an HLA-DR homozygous lymphoblastoid cell line. 21654843 2011
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Analysis of HLA-DRB1 genotypes revealed locus-level T1D association (p = 6.0E-05); DRB1*04:01 appeared predisposing (p < 3.0E-06), and DRB1*14:01 appeared protective (p = 1.7E-02). 31669629 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In Somali children with T1D aged 13.5 ± 5 yr (35% female, disease duration 6.5 ± 3.6 yr), the most common HLA allele was DRB1*03:01 (93%, compared with 45% of Somali controls), followed by DRB1*13:02 (27%). 26854192 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In the Japanese T1D group the association was with haplotype DRB1*0802-DQB1*0302 (P = 0.0008), while in the Swedish T1D patients binding to the b96.11-defined epitope as associated with the presence of high-risk HLA genotypes DR3-DQB1*0201 and/or DR4-DQB1*0302 (P = 0.02). 17956579 2007
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In addition to clarifying the roles of several known T1D HLA alleles and haplotypes, we discovered that the DRB1*08:03-DQB1*06:01 haplotype is protective against T1D. 29383806 2018
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Moreover, the relatives with DRB1*15:01-DQA1*01:02-DQB1*06:02 less frequently expressed autoantibodies associated with higher T1D risk, were less likely to have multiple autoantibodies at baseline, and rarely converted from single to multiple autoantibody positivity on follow-up. 26822082 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The human leukocyte antigen (HLA) class II genes HLA-DRB1, -DQA1 and -DQB1 are the strongest genetic factors for type 1 diabetes (T1D). 21076979 2011
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In this study, we report type 1 diabetes age-of-onset association with HLA class II (DRB1, DQB1, and DPB1) and class I (A) genes in 222 multiplex families from the Human Biological Data Interchange. 10426387 1999
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In addition to HLA-DRB1*15 and DQB1*0602 alleles, DRB1*11, DRB1*13, and DQA1*01 allele groups were associated with protection against the development of type 1 diabetes in Brazilian patients. 12021129 2002
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The frequency of DRB1*04:05-DQB1*04:01, a susceptible haplotype for type 1 diabetes, was significantly lower in patients with AA (TRAb-positive: 8.5%; TRAb-negative: 11.9%) than in those with type 1 diabetes (29.5%, Pc < .0003 and Pc < .0008, respectively). 25734250 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE From this evidence, we conclude that shared disease associations due to the HLA-DRB1-DQB1 loci provide only a partial explanation for the observed increased prevalence of T1D in Sardinian MS patients. 15471889 2004