|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Insulin-dependent diabetes mellitus (IDDM) HLA class II DRB1-DQA1-DQB1 data from four populations (Norwegian, Sardinian, Mexican American, and Taiwanese) have been analyzed to detect the amino acids involved in the disease process.
|
9042932 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DRB1 * 0301-DQA1 * 0501-DQB1 * 0201 haplotype offers a predisposition to type 1 diabetes in North Chinese.
|
11780465 |
2001 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 and DQB1 alleles were determined in 178 AAb-positive and 339 AAb-negative schoolchildren aged 6-17 years without first-degree relatives with T1D and in 274 patients with T1D.
|
14679044 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0301 was significantly increased in the T1D patients along with associated DQB1*0201 followed by DRB1*0401 and DRB1*0405.
|
15245369 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DRB1*0301-DQA1*0501-DQB1*0201 was the most frequent haplotype in both groups but we found a higher proportion of protective T1D haplotypes and Asp(beta57) in the Ab neg group, but in all the cases in combination with susceptible T1D haplotypes.
|
15660729 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*11/DQA1*0505/DQB1*0301 and DQA1*0505/DQB1*0301 were negatively associated with type 1 diabetes (OR=0.27, CI 0.11-0.57; OR=0.07, CI 0.02-0.19).
|
16096857 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*0401, *0402, *0404 and *0405 alleles were all common in DQB1*0302 haplotypes and associated with T1D.
|
16276008 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1 (*)04 and HLA-DQB1 (*)0302 have been detected as risk factors for T1DM in adults and particularly in children (P<0.0001, OR=22.9 and 46.5 respectively).
|
17318773 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 (*)04 and HLA-DQB1 (*)0302 have been detected as risk factors for T1DM in adults and particularly in children (P<0.0001, OR=22.9 and 46.5 respectively).
|
17318773 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0401 confers both the strongest type 1 diabetes risk, and positive association of anti-IA-2, whereas the DRB1*03- DQA1*0501-DQB1*0201 haplotype, associated less strongly with T1D, showed a significant negative association with anti-IA-2 positivity.
|
19429597 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*07:01-DQA1*02:01-DQB1*02:01g is protective for T1D; however, the presence of DQA1*03:01 on the DRB1*07:01-DQB1*02:01g haplotype not only renders the DR7 haplotype not protective but also creates a haplotype with significant T1D risk.
|
21988721 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA DRB1*0405, DRB1*0901 and DRB1*0802-DQB1*0302 haplotypes were positively associated with T1D, while the DRB1*15 haplotypes were negatively associated.
|
22069271 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DRB1 and DQB1 allele frequencies were similar for both A(-) KPD and T2D patients; they did not confer any substantial risk even after considering type 1 diabetes susceptibility and resistance alleles.
|
25511714 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*04:01 and *04:02 were also predisposing for T1D in Arabs.
|
26818122 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*03 as a risk factor for microalbuminuria in same duration of type 1 diabetes: a case control study.
|
27036319 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*04:01-restricted responses toward many of these peptides have been previously described, but responses to a novel pre-proinsulin 9-28 peptide were commonly observed in subjects with T1D.
|
30455401 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*0404, which was decreased in frequency in IDDM subjects, occurred in association significantly more frequently with DQB1*0302 in controls.
|
7495781 |
1995 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.
|
7729610 |
1995 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 allele typing revealed that NIDDM-SF patients positive for anti-GAD were significantly associated with DRB1*0901 (RR = 2.81, P < 0.01), which is one of the susceptible alleles to IDDM.
|
9344701 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
DRB1*0401 was the most prevalent subtype in IDDM patients, whereas DRB1*0404 was decreased in frequency.
|
9356041 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
A decreased TAP2-B phenotype frequency was observed in DRB1*03- and DRB1*04-negative IDDM patients compared with DRB1*03- and DRB1*04-negative normal controls (38.6% vs 63%, pc < 0.05), but was probably related to a combination of different weak LD between DRB1 and TAP2 alleles.
|
8847232 |
1995 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
A new predictive model for insulin-dependent diabetes mellitus susceptibility based on combinations of molecular HLA-DRB1 and HLA-DQB1 pockets.
|
10551417 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A second high risk haplotype, DRB1*0401-DQB1*0302 encoding the DR4-DQ8 serologic specificity, accounted for increased susceptibility both in the total insulin-dependent diabetic population and among DR4-positive patients.
|
7988783 |
1994 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
A strong positive association of DRB1*04-DQA1*0301-DQBl*0302 (OR=5.67, p<0.001) and DRB1*0301-DQA1*0501-DQB1*0201 (OR=6.24, p<0.001) putative haplotypes with IDDM was evident in Jordanian IDDM patients whereas DRB1*1101-DQA1*0505- DQB1*0301 (OR=0.23, p=0.03) was shown to have a protective role against T1D in Jordanians.
|
31742498 |
2019 |