Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. We observed a negative association between the activating KIR2DS1 gene and MS (adjusted OR=0.450, p=0.030) independently from the presence of HLA-DRB1*15 allele.
|
24529855 |
2014 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DRB1*1501, DQB1*0602 and DQB1*0608 alleles were the only positive HLA association with MS.
|
18312478 |
2008 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DR2 haplotype (DRB1*1501, DQB1*0602) on chromosome 6p21 has consistently demonstrated both association and linkage with multiple sclerosis (MS) in case-control and family studies, particularly in Caucasians of Northern European descent.
|
12225902 |
2002 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
However, we show for the first time that HLA-DRB1*15 allele modulates the course of MS for relapsing-remitting (RR) onset patients likely by precipitating the secondary progressive (SP) phase.
|
18615093 |
2008 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The putative haplotype, DRB1*1501.DQA1*0102.DQB1*0602, was weakly positively associated with MS in both races.
|
7761978 |
1995 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS).
|
30836273 |
2019 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Cross-ethnic comparison between the two HLA haplotypes associated with MS in Sardinians and the DRB1*1501 (DR2)-DQA1*0102-DQB1* 0602 haplotype, associated with MS in other Caucasian populations, failed to identify any shared epitopes in the DR and DQ molecules that segregated with disease susceptibility.
|
9668164 |
1998 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the risky genotypes TT and TC were showed to be associated with an increased MS risk, and this was aggravated by the homozygous carriage of the HLA-DRB1*15:01 allele (OR = 2.82 vs. 4.86, p < .0001).
|
30875612 |
2019 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk.
|
18606010 |
2008 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
While in these 397 families, 8 markers showed significant association with MS, through conditional tests we determined that these MOG variants were not associated with MS independently of the main DRB1-DQB1 disease associations.
|
17509152 |
2007 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CNS-specific ANA were more frequent in MS than in NMOSD patients or HCs (13.5% vs 0% for both comparisons, both p < .05) and were associated with HLA-DRB1*15:01 (p = .0174).
|
31835211 |
2020 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The expected MS associated HLA-pattern of Caucasoid patients, however, was found in the MS-only patients (42% carried DRB1*1501-DQB1*0602, 58% carried DQA1*0102), while the prevalence of T1DM susceptibility and 'resistance' alleles was not different from the general population.
|
12149602 |
2002 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although the interaction was not statistically significant, there appeared to be a trend of increasing risk of MS in participants who were homozygous for the HLA-DRB1*1501 allele in association with the more active form of the VDR (Fok1).
|
21816760 |
2012 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association of DRB1*1501-DQB1*0602 haplotype carriage with MS in both Wexford [odds ratio (OR) = 2.95, P= 0.0020, P(cor)= 0.0220] and Donegal (OR = 2.29, P= 0.0030, P(cor)= 0.0420).
|
16948649 |
2006 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the DR2-associated DRB1*1501 allele and DRB5*0101 allele were associated with Western-type MS (41.2%), but not with either Asian-type MS (0%) or healthy control subjects (14.2%).
|
8871575 |
1996 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To closer model presentation of human MOG by astrocytes in MS patients, we generated astrocytes from transgenic mice expressing the MS-associated MHC class II alleles HLA-DR2 (DRB1*1501) and HLA-DR4 (DRB1*0401).
|
16386804 |
2006 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Conventional MS in Japanese people is, like MS in white people, associated with HLA-DRB1*1501, whereas opticospinal MS is associated with HLA-DPB1*0501.
|
12849268 |
2003 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*08:01 allele interacted with smoking to increase MS risk.
|
31573825 |
2019 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls.
|
18952831 |
2008 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: a pilot study.
|
23477965 |
2013 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Results herein offer a model justifying the interaction between the major genetic (HLA-DRB*15) and environmental (vitamin D) factors associated with MS onset.
|
21664963 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between previous exposure to ultraviolet radiation (UVR), vitamin D status at inclusion in the study, and MS risk including the interaction of these factors with HLA-DRB1*15.
|
22289117 |
2012 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Scores were initially calculated using log odds ratio from the HLA-DRB1*1501 allele only, secondly using data from all MS-associated SNPs identified in the 2011 GWAS.
|
27802296 |
2016 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found that, in addition to DR15, DR17 is positively associated with susceptibility to MS; that none of the HLA-DRB1 alleles influences course or outcome in MS; that carriers of DR15 are prone to MS development at an earlier age than noncarriers; and that differences in DR15 positivity rates, after stratification for diagnostic category and examination results, seem to reflect a gradient of phenocopy contamination, with rates increasing in proportion to the degree of clinical or paraclinical verification of the MS diagnosis.
|
10939572 |
2000 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, even for this major susceptibility allele, only a very small fraction of DRB1*1501carriers (<5%) are susceptible to getting MS and for only a minority of MS patients (∼41%) does this allele contribute to their susceptibility.
|
23272039 |
2012 |