|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The most implicated gene is HLA-DRB1, with HLA-DRB1*03:01 the most associated risk allele in both Crohn's disease and ulcerative colitis.
|
31518029 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
IFNα upregulated HLA-DRB1 expression on lupus but not control CD8+ T cells.
|
30674474 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to explore whether TGF-β and IL-6 gene polymorphisms may be associated with SLE and assess the frequency of HLA-DRB1 alleles in Polish systemic lupus erythematosus (SLE) patients.
|
30943147 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this cohort, SNP rs9271366 (tag SNP for HLA-DRB1*15:01) confers the highest risk for SLE among the 13 MHC gene alleles that display association with SLE (p = 8.748E-10; OR = 3.5).
|
31032751 |
2019 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Human leukocyte antigen (HLA)-DRB1*03 is over-represented in LS, and is associated with a good prognosis, whereas HLA-DRB1*15-positive patients have a more chronic course of sarcoidosis.
|
30585624 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm the association between TNF and DRB1 polymorphisms and SLE.
|
29912900 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study demonstrated that the presence of HLA-DRB1*15 was a strong factor that predisposed patients to the development of SLE and LN, but did not influence kidney graft survival.
|
29421495 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Next-generation sequencing analysis of the MHC region (previously suggested to be a hot region in atypical psychosis) using HLA typing (HLA-DRB1) revealed a common vulnerability with SLE (systemic lupus erythematosus) among five patients.
|
30323194 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The association of homozygous deletion of C4A and SLE is accompanied by the presence of HLA-DRB1*0301 without a proven pathophysiological mechanism.
|
29050534 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Case-control studies on HLA-DRB1 and SLE were searched from PubMed, Elsevier Science, Springer Link, Medline, and Cochrane Library database as of June 2018.
|
30511687 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Certain haplotype combinations, DRB1*07-DQβ1*03 (OR: 2.21; 95% CI:1.29-3.79, p<sub>c</sub> = 0.06, p = 0.00036) and DRβ1*07-DQβ1*05 (OR: 2.51, 95% CI: 1.34-4.71, p<sub>c</sub> = 0.07, p = 0.00039), had positive associations whereas DRβ1*14-DQβ1*03 (OR: 0.14, 95% CI: 0.061-0.36, p<sub>c</sub> = 2.34 × 10<sup>-5</sup>, p = 1.30 × 10<sup>-6</sup>) were found to have a significant negative association with SLE.
|
29439646 |
2018 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis.
|
30009963 |
2018 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Together, these studies reveal the presence of linked <i>in situ</i> recognition of vimentin by both T- and B-cells in HLA-DRB1*03<sup>+</sup> sarcoidosis patients, associated with a selective humoral immune response to the vimentin C-terminus.
|
30038611 |
2018 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the logistic regression models evaluating the association between HLA alleles and chronic sarcoidosis adjusted for rs1049550 and rs2076530, only DRB1*03 was significantly associated with disease resolution.
|
27662826 |
2018 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have previously demonstrated that in our series HLADRB1* 03:01 and haplotype HLA-DRB1*04:01-DPB1*04:01 are associated with good prognosis sarcoidosis.
|
29229112 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
HLA-C*01 is a Risk Factor for Crohn's Disease.
|
26891255 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, our observations showed that HLA-G 14bp ins allele represents a genetic contribution on early-onset SLE independent of DRB1.
|
27331404 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Classic HLA allele imputation analysis identified HLA-DRB1*1501 and HLA-DQB1*0602, each highly correlated with one another, as most strongly associated with SLE.
|
26663301 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE.
|
26919467 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We detected 6 HLA-DRB1 alleles that were associated with SLE in Koreans.
|
26663868 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found an increase in risk of maternal SLE associated with exposure to children who inherited DRB1*04:01 from their father (OR 1.9; 95% CI, 1.1-3.2), among *04:01 allele-negative mothers.
|
27388144 |
2016 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Depending on age categories compared, single nucleotide polymorphisms in POU5F1, TNFSF15, and HLA DRB1*501 were associated with age of Crohn's disease diagnosis.
|
25664710 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls).
|
26605347 |
2015 |