AOAH, acyloxyacyl hydrolase, 313

N. diseases: 23; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0236733
Disease: Amphetamine-Related Disorders
Amphetamine-Related Disorders 		0.300 Biomarker group CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0236804
Disease: Amphetamine Addiction
Amphetamine Addiction 		0.300 Biomarker disease CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0236807
Disease: Amphetamine Abuse
Amphetamine Abuse 		0.300 Biomarker disease CTD_human Genome-wide association for methamphetamine dependence: convergent results from 2 samples. 18316681 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.020 Biomarker disease BEFREE Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis. 17989521 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.020 Biomarker disease BEFREE Our results indicate that polymorphisms in markers within the AOAH gene are associated with risk of asthma and associated quantitative traits (IgE and cytokine levels) among asthmatic subjects and their families in Barbados, and there is an interactive effect on tIgE and asthma concentrations between an AOAH marker and the functional CD14(-260)C >T polymorphism. 16815140 2006
CUI: C0003467
Disease: Anxiety
Anxiety 		0.010 Biomarker disease BEFREE We previously showed that AOAH-deficient mice mimicked interstitial cystitis/bladder pain syndrome, a condition frequently associated with comorbid anxiety and depression. 31017816 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.010 Biomarker group BEFREE We previously showed that AOAH-deficient mice mimicked interstitial cystitis/bladder pain syndrome, a condition frequently associated with comorbid anxiety and depression. 31017816 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 Biomarker disease BEFREE PPARγ did not affect AA-dependent <i>Crf</i> expression in vitro, and conditional <i>Ppar</i>γ knockout did not alter the AOAH-deficient depressive phenotype, despite previous studies implicating PPARγ as a therapeutic target for depression. 31017816 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 Biomarker disease BEFREE PPARγ did not affect AA-dependent <i>Crf</i> expression in vitro, and conditional <i>Ppar</i>γ knockout did not alter the AOAH-deficient depressive phenotype, despite previous studies implicating PPARγ as a therapeutic target for depression. 31017816 2019
CUI: C0282488
Disease: Interstitial Cystitis
Interstitial Cystitis 		0.010 Biomarker disease BEFREE We previously showed that AOAH-deficient mice mimicked interstitial cystitis/bladder pain syndrome, a condition frequently associated with comorbid anxiety and depression. 31017816 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 Biomarker phenotype BEFREE PPARγ did not affect AA-dependent <i>Crf</i> expression in vitro, and conditional <i>Ppar</i>γ knockout did not alter the AOAH-deficient depressive phenotype, despite previous studies implicating PPARγ as a therapeutic target for depression. 31017816 2019
CUI: C0600040
Disease: Chronic interstitial cystitis
Chronic interstitial cystitis 		0.010 Biomarker disease BEFREE We previously showed that AOAH-deficient mice mimicked interstitial cystitis/bladder pain syndrome, a condition frequently associated with comorbid anxiety and depression. 31017816 2019
CUI: C3160917
Disease: Bladder pain syndrome
Bladder pain syndrome 		0.010 Biomarker disease BEFREE We previously showed that AOAH-deficient mice mimicked interstitial cystitis/bladder pain syndrome, a condition frequently associated with comorbid anxiety and depression. 31017816 2019
CUI: C0030794
Disease: Pelvic Pain
Pelvic Pain 		0.010 Biomarker phenotype BEFREE These findings indicate that AOAH modulates pelvic pain severity, suggesting that allelic variation in Aoah influences pelvic pain in IC. 29118019 2018
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 Biomarker disease BEFREE We report here that acyloxyacyl hydrolase (AOAH), a host lipase that degrades and inactivates LPS, renders mice more susceptible to house dust mite (HDM)-induced allergic asthma. 30021797 2018
CUI: C0404484
Disease: Chronic pelvic pain of female
Chronic pelvic pain of female 		0.010 AlteredExpression phenotype BEFREE Finally, AOAH-deficient mice had significantly higher levels of bladder vascular endothelial growth factor, an emerging marker of chronic pelvic pain in humans. 29118019 2018
CUI: C0850758
Disease: Pelvic pain female
Pelvic pain female 		0.010 Biomarker phenotype BEFREE These findings indicate that AOAH modulates pelvic pain severity, suggesting that allelic variation in Aoah influences pelvic pain in IC. 29118019 2018
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.010 Biomarker disease BEFREE Inactivation of LPS by AOAH is a previously unappreciated mechanism for promoting resolution of pulmonary inflammation/injury induced by Gram-negative bacterial infection. 28622363 2017
CUI: C0085423
Disease: Gram-Negative Bacterial Infections
Gram-Negative Bacterial Infections 		0.010 Biomarker group BEFREE Inactivation of LPS by AOAH is a previously unappreciated mechanism for promoting resolution of pulmonary inflammation/injury induced by Gram-negative bacterial infection. 28622363 2017
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.010 Biomarker disease BEFREE Inactivation of LPS by AOAH is a previously unappreciated mechanism for promoting resolution of pulmonary inflammation/injury induced by Gram-negative bacterial infection. 28622363 2017
CUI: C0149516
Disease: Chronic sinusitis
Chronic sinusitis 		0.010 GeneticVariation disease BEFREE Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study. 22723975 2012
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.010 GeneticVariation disease BEFREE Although these studies are subject to methodologic difficulties, associations of CRS and polymorphisms in more than 30 genes have been published, with single nucleotide polymorphisms in 3 (IL1A, TNFA, AOAH) replicated. 21499907 2011
CUI: C0036690
Disease: Septicemia
Septicemia 		0.010 Biomarker disease BEFREE Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis. 17989521 2007
CUI: C0243026
Disease: Sepsis
Sepsis 		0.010 Biomarker disease BEFREE Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis. 17989521 2007