|
Amebiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study reveals that Eh-induced active secretion of the HMGB1 plays a key role in shaping the pro-inflammatory landscape critical in innate host defense against amebiasis.
|
31772322 |
2020 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
The purpose of the present study was to investigate the association of HMGB1 and its receptor, toll-like receptor (TLR) 4 with proinflammatory interleukins in AR patients.
|
31739216 |
2020 |
|
Amebic colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study reveals that Eh-induced active secretion of the HMGB1 plays a key role in shaping the pro-inflammatory landscape critical in innate host defense against amebiasis.
|
31772322 |
2020 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subcellular epithelial protein (HMGB1, p53, RUNX3) expression, alongside expression of CD20, CD4, CD8 and Foxp3 to characterise stromal B lymphocyte, and helper, cytotoxic and regulatory T-lymphocyte cell infiltrate, respectively, was assessed by immunohistochemistry in 218 human tissue samples including normal oesophageal/gastric biopsies (n = 39), BO (non-dysplasia, dysplasia, non-dysplastic background from progressors to dysplasia or cancer, n = 121) and oesophageal adenocarcinoma (n = 58).
|
31831860 |
2020 |
|
Cocaine Dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies of HMGB1 in the CNS have largely focused on immune function, and the role of HMGB1 in neurons and cocaine addiction remains unknown.
|
31056833 |
2020 |
|
Drug Dependence
|
0.010 |
Biomarker
|
group |
BEFREE |
These data unveil the role of HMGB1 in neurons and provide the evidence for the HMGB1 involvement in drug addiction.
|
31056833 |
2020 |
|
Exacerbation of idiopathic pulmonary fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of HMGB1 were associated with earlier onset of AE in stable IPF patients and with shorter survival in AE-IPF patients (P = 0.030 and 0.001, respectively).
|
31270920 |
2020 |
|
Post traumatic osteoarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
SDF-1α rather than HMGB1 might serve as a protein marker for monitoring the development of PTOA in the ACL-D knee, especially in female patients.
|
31727431 |
2020 |
|
Amnesia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, the study summarizes several significant protective functions afforded by CXCR7 against HMGB1 induced disbalance in neuroimmunological axis, neurodegeneration and memory loss and thereby provides a new paradigm for strategic development of novel therapeutics against neurodegenerative diseases with dementia as a common symptom.
|
31505255 |
2019 |
|
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, HMGB1 binding with TLR2 receptor functions in a paracrine manner to affect CD133<sup>-</sup> pancreatic cancer cells dedifferentiation via activating Hippo-YAP pathway and HIF-1α expression in oxygen independent manner in vitro and in vivo.
|
31558702 |
2019 |
|
beta Thalassemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Considering the role of reactive oxygen species (ROS) in the pathophysiology of thalassaemia, we focused on differentially expressed genes involved in metabolic pathways triggered by ROS, such as inflammation and apoptosis, and, from these, we selected the Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and High Mobility Group Box1 (HMGB1) genes, whose role in BT is not well established.
|
31218684 |
2019 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of this pilot study suggest that HMGB1 might be a specific peripheral marker of inflammation in BD.
|
31203140 |
2019 |
|
Bronchiolitis Obliterans
|
0.010 |
Biomarker
|
disease |
BEFREE |
HMGB1 blockade significantly improves luminal fibrous obliteration in a murine model of bronchiolitis obliterans syndrome.
|
30508580 |
2019 |
|
Malignant neoplasm of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results show that polyamine-dependent release of HMGB1 promotes the expansion of stem cell-like subpopulations in arsenic-transformed keratinocytes while also increasing their invasiveness, suggesting that polyamines may be a potential therapeutic target for the prevention and treatment of arsenic-initiated skin cancers.
|
31190067 |
2019 |
|
CNS disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
One of these drugs, anti-HMGB1 monoclonal antibody (mAb), is highly specific for HMGB1 and has been shown to be effective for the treatment of a wide range of CNS diseases when modeled in animals, including stroke, traumatic brain injury, Parkinson's disease, epilepsy and Alzheimer's disease.
|
31105025 |
2019 |
|
Cholangitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Postoperative serum HMGB1 and reflux cholangitis indicated recurrence and unfavorable prognosis of PHCCA.
|
30177842 |
2019 |
|
Choledochal Cyst
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis also revealed increased positive immunostaining for HMGB1 in BA liver tissues as compared with CC tissues.
|
29909604 |
2019 |
|
Collagen Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
HMGB-1 is considered as an essential facilitator in diseases such as sepsis, collagen disease, atherosclerosis, cancers, arthritis, acute lung injury, epilepsy, myocardial infarction, and local and systemic inflammation.
|
31215389 |
2019 |
|
Presenile dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, the study summarizes several significant protective functions afforded by CXCR7 against HMGB1 induced disbalance in neuroimmunological axis, neurodegeneration and memory loss and thereby provides a new paradigm for strategic development of novel therapeutics against neurodegenerative diseases with dementia as a common symptom.
|
31505255 |
2019 |
|
Toxic Epidermal Necrolysis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Preblistered SJS/TEN skin showed decreased epidermal nuclear HMGB1 expression in upper epidermis vs. healthy or MPE skin but retained basal/suprabasal expression.
|
30613954 |
2019 |
|
Epilepsy, Generalized
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association Analysis of Interleukin-1β, Interleukin-6, and HMGB1 Variants with Postictal Serum Cytokine Levels in Children with Febrile Seizure and Generalized Epilepsy with Febrile Seizure Plus.
|
31591845 |
2019 |
|
Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since recombinant human soluble thrombomodulin (RH-TM) has anti-inflammatory properties through neutralizing high-mobility group box 1 protein (HMGB1), the protective effects of RH-TM were examined in anti-glomerular basement membrane (GBM) glomerulonephritis (GN) in Wistar-Kyoto rats.
|
29982644 |
2019 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis.
|
30860623 |
2019 |
|
Guillain-Barre Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that signaling between resistin and HMGB1 might be a potential therapeutic target in GBS.
|
30826699 |
2019 |
|
Hemolytic-Uremic Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Involvement of high mobility group box 1 in the pathogenesis of severe hemolytic uremic syndrome in a murine model.
|
31482731 |
2019 |