HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015967
Disease: Fever
Fever
0.340 Biomarker phenotype BEFREE The spontaneous NETs from patients with cutaneous manifestations and fever had higher cargo of HMGB-1 compared with patients in remission. 31365336 2020
CUI: C0015967
Disease: Fever
Fever
0.340 Biomarker phenotype BEFREE Higher levels of pro-inflammatory cytokines and HMGB-1 could be correlated with fever which was observed within 7 dpi in all the infected piglets and additionally around 13 dpi in the animal that died on 17 dpi. 29895396 2019
CUI: C0015967
Disease: Fever
Fever
0.340 GeneticVariation phenotype BEFREE Major up-regulation was demonstrated for the Janus kinase/signal transducer and activators of transcription (JAK/STAT) pathway including, in particular, CD177, S100A8, S100A9 and S100A12, accounting for the thrombocytosis; a large number of interleukins, their receptors and activators, accounting for the febrile apathic state; and the high mobility group box 1 (HMBG1) gene, possibly accounting for part of the intestinal symptoms. 28984903 2018
CUI: C0015967
Disease: Fever
Fever
0.340 Biomarker phenotype CTD_human Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. 19265175 2009
CUI: C0015967
Disease: Fever
Fever
0.340 AlteredExpression phenotype BEFREE Recently identified biological activities of HMGB1 include activation of macrophages/monocytes to release proinflammatory cytokines, upregulation of endothelial adhesion molecules, stimulation of epithelial cell barrier failure, and mediation of fever and anorexia. 14871456 2004