HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Disease: Necrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027540
Disease: Necrosis
Necrosis 		0.300 Biomarker phenotype CTD_human High mobility group box 1 (HMGB1) protein is secreted by activated cells of the innate immune system and/or released by injured tissues and necrotic cells; HMGB1 up-regulates proinflammatory cytokines in several inflammatory diseases. 22178603 2012
CUI: C0027540
Disease: Necrosis
Necrosis 		0.300 Biomarker phenotype CTD_human Hypoacetylated HMGB1 (necrosis indicator), caspase-cleaved K18 (apoptosis indicator), and full-length K18 (necrosis indicator) present in serum showed strong correlations with the histological time course of cell death and was more sensitive than alanine aminotransferase activity. 19783637 2009