HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 AlteredExpression disease BEFREE Higher levels of HMGB1 were associated with earlier onset of AE in stable IPF patients and with shorter survival in AE-IPF patients (P = 0.030 and 0.001, respectively). 31270920 2020
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 AlteredExpression disease BEFREE In conclusion, miR-627 may be a potential agent that targets HMGB1 to inhibit its expression, thereby improving TGF-β1-induced PF in vitro. 30536600 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease BEFREE Bleomycin (BLM)-induced PF in Nrf2-knockout (Nrf2<sup>-/-</sup> ) and wild-type (WT) mice and transforming growth factor β1 (TGF-β1)-induced EMT in rat type II alveolar epithelial cell line (RLE-6TN) and human alveolar epithelial cell line (A549) were established to observe the relationship among Nrf2, HMGB1, and EMT by western blot and immunohistochemistry. 30370641 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease BEFREE This study demonstrates the down-regulator of HMGB1, EP, as a potential therapeutic agent for pulmonary fibrosis, as assessed by a non-invasive HPXe MRI protocol. 29526883 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease BEFREE This study investigated the roles of HMGB1 and thrombin in the pathophysiology of bleomycin-induced pulmonary fibrosis and the efficacy of recombinant human soluble thrombomodulin (rhTM). 29212801 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease BEFREE Therefore, the present study aimed to examine the potential molecular mechanisms that underlie HMGB1‑induced lung fibrosis via the regulation of NF‑κB and TGF‑β1. 28339089 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease BEFREE However, whether aerobic glycolysis contributes to HMGB1-induced fibroblast proliferation and ECM production in PF has not yet been determined. 28571757 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease CTD_human Mounting evidence indicates that high-mobility group box 1 (HMGB1) is involved in pulmonary fibrosis. 27616297 2016
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease BEFREE An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. 25582705 2015
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.390 Biomarker disease LHGDN In bleomycin-induced pulmonary fibrosis in mice, HMGB1 protein was predominantly up-regulated in bronchiolar epithelial cells at early phase and in alveolar epithelial and inflammatory cells in fibrotic lesions at later phase. 18441281 2008