HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Disease: Myocardial Ischemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.350 Biomarker disease BEFREE The main focus of this review is to provide an overview of the effects of HMGB1 in different ischemic heart diseases and to discuss its functions in these pathological conditions. 30529040 2019
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.350 AlteredExpression disease BEFREE Quercetin attenuates myocardial ischemia-reperfusion injury via downregulation of the HMGB1-TLR4-NF-κB signaling pathway. 29887944 2018
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.350 Biomarker disease BEFREE Both the high‑mobility group box 1 protein (HMGB1) and interleukin (IL)‑17A serve important roles in myocardial ischemia and reperfusion injury. 29115425 2018
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.350 AlteredExpression disease BEFREE This protective effect is correlated with downregulation of HMGB1 and downstream proinflammatory cascades, which could be useful for the development of novel treatment for ischemic heart disease. 26498282 2016
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.350 Biomarker disease BEFREE C57BL/6 wild-type (WT) or TLR2(-/-)-mice were injected with vehicle, HMGB1, or HMGB1 BoxA one hour before myocardial ischemia (30 min) and reperfusion (24 hrs). 24371373 2013
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.350 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005