HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Disease: Squamous cell carcinoma of esophagus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.360 Biomarker disease BEFREE HMGB1 is expected to be a potential target for ESCC therapy and radiosensitization. 29968320 2019
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.360 Biomarker disease BEFREE HMGB1 may be used as a predictor of poor response to radiotherapy in ESCC patients. 30755598 2019
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.360 Biomarker disease BEFREE Thus, effective methods of treatment include combining immunotherapy with targeting PD1<sup>+</sup> TAMs and tumor-derived exosomal HMGB1 to resuscitate immune function in individuals suffering from ESCC. 30796203 2019
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.360 AlteredExpression disease BEFREE As a result, both HMGB1 and calreticulin expression levels were significantly upregulated after NAC in both breast cancer and ESCC tissues. 29138861 2018
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.360 Biomarker disease BEFREE Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma. 29567990 2018
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.360 AlteredExpression disease BEFREE HMGB1 expressed highly in the nuclei and cytoplasm of carcinoma cells as well as the extracellular space in ESCC and was associated with lymph node metastasis, MLD, the expression of VEGF-C, TNM stage and the prognosis of patients (P < 0.05 or P < 0.01). 22544356 2012
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.360 Biomarker disease CTD_human The results showed that both HSP70 and HMGB1 can induce autoantibody response in ESCC sera and have higher expression in ESCC tissues. 21517111 2011