Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Male C57BL/6 mice with or without endotoxaemia were exposed to MV (10 mL/kg) for 8 hours after administrating either 100 mg/kg of EP or 100 mg/kg of anti-HMGB1 antibody.
|
31339670 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Here we discovered that hepatocyte-released high mobility group box 1 (HMGB1) was required for caspase-11-dependent pyroptosis and lethality in endotoxemia and bacterial sepsis.
|
30314759 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote survival during endotoxemia and experimental sepsis.
|
30134814 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Our in vivo and in vitro studies show dioscin protects hippocampus from endotoxemia induced cascade neuro-inflammation through neurotransmitter 5-HT and HMGB-1/TLR4 signaling pathway, which accounts for the dioscin therapeutic effect in behavioral tests.
|
28059131 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
A Dalbergia odorifera extract improves the survival of endotoxemia model mice by inhibiting HMGB1 release.
|
28403838 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Pre-clinically, administration of neutralising ovine anti-HMGB1 polyclonal antibodies improved survival in murine endotoxaemia and caecal ligation and puncture-induced sepsis models, and altered early cytokine profiles to one which corresponded to patterns observed in the surviving patient cohort.
|
28724977 |
2017 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
These observations suggest that identification of agents, including those in the herb <i>C. longa</i>, that can inhibit HMGB1 production and/or activity may aid the treatment of endotoxemia.
|
28929026 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Highlights of this study include: human SAA is possibly only expressed in a subset of septic patients; SAA induces HMGB1 release via TLR4 and RAGE receptors; SAA supplementation worsens the outcome of lethal endotoxemia; whereas SAA-neutralizing antibodies confer protection against lethal endotoxemia and sepsis.
|
26052716 |
2015 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
High mobility group box-1 (HMGB1) protein is involved in the process of endotoxemia.
|
20943459 |
2010 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, we wanted to determine whether tissue and circulating levels of HMGB1 are increased further in the absence of HO-1 during endotoxemia, and whether this increase may contribute to the pathobiology of endotoxemia.
|
19097991 |
2009 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
RGD |
High mobility group box 1 induces a negative inotropic effect on the left ventricle in an isolated rat heart model of septic shock: a pilot study.
|
18503231 |
2008 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Passive immunization with anti-HMGB1 antibodies confers significant protection against lethal endotoxaemia, sepsis, arthritis and lipopolysaccharide-induced acute lung injury, even when antibody administration is delayed until after the early TNF responses have resolved.
|
14871456 |
2004 |