HMGB1, high mobility group box 1, 3146

N. diseases: 724; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 Biomarker disease BEFREE These data demonstrate that 2% H2 inhalation may be a promising therapeutic strategy for intestinal injuries caused by severe sepsis through the regulation of HO-1 and HMGB1 release. 28234792 2017
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 Biomarker disease BEFREE Inhibition of high mobility group box 1 (HMGB1) and restoration of endothelial integrity is emerging as an attractive therapeutic strategy in the management of severe sepsis or septic shock. 28830206 2017
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 GeneticVariation disease BEFREE We investigated the associations of a single nucleotide polymorphism (SNP; rs1045411) in HMGB1 with various clinical parameters, severity, and prognosis in patients with sepsis, severe sepsis, or septic shock. 26632390 2016
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 Biomarker disease CTD_human Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo. 23146691 2013
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 Biomarker disease BEFREE A pathogenic role for high-mobility group box 1 (HMGB1) protein has been postulated in severe sepsis. 21849480 2011
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.340 Biomarker disease CTD_human Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. 19265175 2009