HMOX1, heme oxygenase 1, 3162

N. diseases: 666; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009319
Disease: Colitis
Colitis
0.570 AlteredExpression disease BEFREE Furthermore, ZFE effectively modulated the mRNA expression of redox-sensitive transcription factors, such as nuclear factor (erythroid-derived 2)-like 2 and heme oxygenase-1, downregulated the expression of p38 mitogen-activated protein kinase, and upregulated that of vascular endothelial growth factor A and interleukin-1β in AcOH-induced colitis in rats. 29518435 2018
CUI: C0009319
Disease: Colitis
Colitis
0.570 AlteredExpression disease BEFREE Our data indicate that ESG, digested with α-amylase to RG, suppresses DSS- and TNBS-induced colitis by increasing the expression of HO-1 in the large intestine of mice. 28257879 2017
CUI: C0009319
Disease: Colitis
Colitis
0.570 Biomarker disease BEFREE This study was undertaken to elucidate the Bach1/HO-1 system's effects on the pathogenesis of experimental colitis. 23446334 2013
CUI: C0009319
Disease: Colitis
Colitis
0.570 Biomarker disease BEFREE In this study, we found that increased expression of Mkp-1, Nrf2, and heme oxygenase 1 (Ho-1) was correlated in colonic tissues in patients with ulcerative colitis and Crohn's disease, as well as wild-type mice with colitis induced by dextran sodium sulfate (DSS). 30061089 2018
CUI: C0009319
Disease: Colitis
Colitis
0.570 Biomarker disease BEFREE 15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> ameliorates dextran sulfate sodium-induced colitis in mice through heme oxygenase-1 induction. 31704099 2019
CUI: C0009319
Disease: Colitis
Colitis
0.570 AlteredExpression disease BEFREE PHB Tg/Nrf2(-/-) mice mimicked PHB Tg mice, with attenuated DSS- or TNBS-induced colitis and induction of colonic HO-1 and NQO-1 expression, despite deletion of Nrf2. 23494124 2013
CUI: C0009319
Disease: Colitis
Colitis
0.570 AlteredExpression disease BEFREE We also found that treatment with AcEGCG increased heme oxygenase-1(HO-1) expression via activation of extracellular signal-regulated protein kinase (ERK)1/2 signaling and acetylation of NF-E2-related factor 2 (Nrf2), thereby abating DSS-induced colitis. 22409325 2012
CUI: C0009319
Disease: Colitis
Colitis
0.570 Therapeutic disease CTD_human An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. 21444764 2011
CUI: C0009319
Disease: Colitis
Colitis
0.570 Therapeutic disease CTD_human Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. 16365149 2005
CUI: C0009319
Disease: Colitis
Colitis
0.570 Therapeutic disease RGD BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats. 21853095 2011
CUI: C0009319
Disease: Colitis
Colitis
0.570 Biomarker disease RGD A vegetal ALA-rich formula decreases the expression of ICAM-1, VCAM-1, and VEGFR-2 and independently of HO-1 in rats with TNBS-induced colitis. 22261574 2012