HMOX1, heme oxygenase 1, 3162

N. diseases: 666; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE HMOX1 rs743811 associated with chronic kidney disease stage (OR=3.0, P=0.0001) in the University of Illinois cohort and end-stage renal disease (OR=10.0, P=0.0003) in the Walk-Treatment of Pulmonary Hypertension and Sickle cell Disease with Sildenafil Therapy cohort. 26206798 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution. 21787712 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE The impaired D5R regulation of HO-1 and ROS production contributes to the pathogenesis of hypertension in D5(-/-) mice. 23425954 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE We recently demonstrated that heme oxygenase-1 (HO-1) protects against hypertension in a rat model of placental ischemia; however, whether HO-1 regulation of β-ENaC contributes to the beneficial effects of HO-1 is unknown. 24553299 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE In this work, we have addressed whether expression of heme oxygenase-1 (HO-1), an antioxidant enzyme, becomes altered in these cells upon Ang II treatment or under hypertension conditions. 18515325 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE The AA genotype of HMOX-1 is associated with an increased incidence of hypertension in women. 12872043 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE On balance, however, the strategies to target heme oxygenase-1 as described in this review offer promising therapeutic approaches to clinicians for the effective management of hypertension and renal function. 19027871 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE Finally, individuals with unfavourable HMOX1 gene promoter length had increased prevalence of arterial hypertension and reduced cumulative survival after a median follow-up of 7.23 years. 26516175 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE For comparison, HO-1 levels were assayed in RPE cells from four donor eyes with long-standing hypertension. 9134328 1997
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE This study evaluated in 16 pediatric renal transplant patients, divided in two groups based on the presence of post-transplant hypertension, the oxidative stress status measuring the gene expression (reverse transcription-polymerase chain reaction) of two major oxidative stress-related proteins, p22(phox) and heme oxygenase-1 (HO-1). 16860128 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE The aim of the present study was to explore the mechanisms of depression and hypertension by examining the expression and interaction of renin/prorenin receptor (PRR) and heme oxygenase 1 (HO-1) in vascular endothelial cells. 31410134 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group BEFREE Regarding to the (GT)n repeats, the LL genotype showed a higher odds ratio for the development of albuminuria only in patients with hypertension when compared to the S allele.In conclusion, the T(-413)A SNP in the HO-1 promoter is significantly associated with albuminuria development in type 2 diabetes patients, especially with longer duration and poor glycemic control. 26512585 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group BEFREE The multifactor-dimensionality reduction analyses results did not show any interaction between the HMOX1 and HMOX2 genes underlying the development of hypertension. 19886851 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. 20957739 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 AlteredExpression group BEFREE Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension. 23391748 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Therapeutic group CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group CTD_human Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. 22349312 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Therapeutic group CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Therapeutic group CTD_human Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. 22349312 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 GeneticVariation group LHGDN The AA genotype of HMOX-1 is associated with an increased incidence of hypertension in women. 12872043 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker group RGD Selective regulation of blood pressure by heme oxygenase-1 in hypertension. 12215473 2002