HMOX1, heme oxygenase 1, 3162

N. diseases: 666; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease BEFREE Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin. 26801320 2016
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease BEFREE Based on our previous finding that protease-activated receptor 2 (PAR-2) regulates hemophagocytosis of oral squamous cell carcinoma (SCC) cells, which induces their heme oxygenase 1-dependent keratinization, we have formulated a hypothesis that PAR-2 functions in wider activities of SCC cells. 25912757 2015
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease BEFREE The LL genotype and L-allele carrying genotypes (LL+LS) of HO-1 (GT)n repeat polymorphism are potential genetic factors for developing squamous cell carcinoma. 24969894 2014
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease BEFREE Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. 22580187 2012
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease BEFREE HMOX-1 promoter polymorphism might be considered as a potential prognostic marker in OSCC patients. 18312299 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 AlteredExpression disease LHGDN Oral squamous cell carcinoma also showed elevated expression of HO-1, but this level was not higher than in severe OED or carcinoma in situ. 18272347 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 Biomarker disease LHGDN Functional polymorphism in NFKB1 promoter is related to the risks of oral squamous cell carcinoma occurring on older male areca (betel) chewers. 16387424 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease LHGDN Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. 15365571 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 GeneticVariation disease BEFREE Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. 15365571 2004
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.090 AlteredExpression disease BEFREE These findings further support the proposition that high heme oxygenase-1 expression in oral SCCs can be useful in identifying patients at low risk of lymph node metastasis. 10378773 1999