Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE <b>Abbreviations: CI</b> = confidence interval; <b>CKD</b> = chronic kidney disease; <b>DM</b> = diabetes mellitus; <b>DN</b> = diabetic nephropathy; <b>DR</b> = diabetic retinopathy; <b>eGFR</b> = estimated glomerular filtration rate; <b>ESRD</b> = end-stage renal disease; <b>HbA1c</b> = glycated hemoglobin; <b>HO-1</b> = heme oxygenase 1; <b>HR</b> = hazard ratio; <b>IFTA</b> = interstitial fibrosis and tubular atrophy; <b>log-BIL</b> = log-transformed baseline serum bilirubin; <b>T2DM</b> = type 2 diabetes mellitus. 30865534 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Gene expression of both non-heme (SLC40A1 (ferroportin), SLC11A2) and heme iron (SLC46A1 (HCP1), HMOX1) transporters is analyzed in 38 small intestine tissue samples [11 with normal glucose tolerance, 14 with glucose intolerance (GI), and 13 with newly diagnosed type 2 diabetes (T2D)]. 29082606 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Here, heat shock proteins Hsp70 and Hsp 90, adiponectin, and heme oxygenase-1 (HO-1, Hsp32) are profiled in peripheral blood mononuclear cells (PBMC) and serum from 25 T2DM patients and 25 healthy control subjects. 29752628 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE The involvement of heme oxygenase 1 (HO-1) in the modulation of the antinociceptive effects of opioids in type 1 diabetes has been demonstrated but the role played by the transcription factor Nrf2 in the regulation of painful neuropathy and in the effects and expression of δ-opioid receptors (DOR) in type 2 diabetes, has not been studied. 28700700 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE <i>Ex vivo</i> experiments indicated that Nrf-2 and HO-1 expression is reduced in T2DM <i>versus</i> non-T2DM OA cartilage (0.57-fold Nrf-2 and 0.34-fold HO-1), and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) release was increased in samples with low HO-1 expression. 28684418 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The SM genotype in HO1 gene promoter and ferritin levels were associated with higher risk for type-2 diabetes and for having a higher marker of inflammation, which is the main risk factor for the development of chronic diseases. 27473828 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Multiple logistic regression analysis, however, showed that only rs2364723 significantly reduced levels of serum HMOX1 in T2DM patients for the GG genotype carriers compared with participants with CG+CC genotype. 27374075 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE OxPAPC concentrations (in PBMC and plasma), MDA levels (in plasma), the expressions of the glucose-regulated protein 78 kDa (or BiP) as representative of UPR, and of the CCAAT/enhancer-binding protein homologous protein as representative of ER apoptosis were significantly higher (p < 0.01) in T2DM with respect to C. IkBα expression was significantly lower (p < 0.01) in T2DM as well as Nrf2 and HO-1. 25511473 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Regarding to the (GT)n repeats, the LL genotype showed a higher odds ratio for the development of albuminuria only in patients with hypertension when compared to the S allele.In conclusion, the T(-413)A SNP in the HO-1 promoter is significantly associated with albuminuria development in type 2 diabetes patients, especially with longer duration and poor glycemic control. 26512585 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Therapeutic disease RGD Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes. 23731386 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Persons carrying longer (GT)(n) repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes. 20682519 2010
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Few studies regarding the topographical expression of heme oxygenase-1 (HO-1) and its pathophysiological role in human coronary atherosclerotic lesions, particularly in relation to type 2 diabetes mellitus (DM) and intimal angiogenesis, have been reported. 18620357 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE These results support an association between the HO-1 (GT)(n) microsatellite polymorphism, HO-1 expression levels, and the odds of T2DM. 19696228 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease LHGDN Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. 17991645 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with iron status in persons with type 2 diabetes mellitus. 17991645 2007
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE NADPH oxidase (p22(phox)) and HO-1 gene expression were probed by RT-PCR using leucocytes from patients with Type 2 diabetes without (n = 19) and with microangiopathy (n = 20) and non-diabetic subjects (n = 17). 16759310 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Therapeutic disease CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Therapeutic disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366 2005
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. 12941774 2003
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Decompensated type 2 diabetes is associated with increased p22(phox) and HO-1 gene expressions in circulating monocytes; the metabolic normalization reduces but does not normalize this activation. 12679469 2003
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease CTD_human Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. 12136229 2002
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Therapeutic disease CTD_human Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. 12136229 2002