HMOX1, heme oxygenase 1, 3162

N. diseases: 666; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE Bilirubin levels may become elevated as a result of heme oxygenase-1 activation, occurring in exercise-induced acute kidney injury in patients with RHUC; this phenomenon suggests renal ischemia-reperfusion injury. 31771519 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 AlteredExpression disease BEFREE Lowering Hcy level or HO-1 induction might be a potential therapeutic strategy to improve the outcome of AKI. 30084650 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 GeneticVariation disease BEFREE We genotyped 300 patients with severe AKI (KDIGO 2 or 3) and 353 controls without AKI (KDIGO 0) for the guanine-thymine (GTn) repeat in the promoter region of the HMOX1 gene. 31120979 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE However, the use of hemin-induced HO-1 to prevent AKI-induced ALI remains poorly investigated. 31530210 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 AlteredExpression disease BEFREE Additionally, the PDK4 and HO-1 gene expression only increased in the ISS group on day 4 post-AKI. 31001374 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE 6-Shogaol protects against ischemic acute kidney injury by modulating NF-κB and heme oxygenase-1 pathways. 31313953 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 AlteredExpression disease BEFREE In summary, we documented that TLR2 plays a protective role in cisplatin-induced AKI progression, in part, by a mechanism associated with autophagy up-regulation, considering that its interplay with HO-1 can promote renal tissue recover. 29500224 2018
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective against AKI because of its antiapoptotic and anti-inflammatory properties. 28515173 2018
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE Therefore, HO-1 might be an interesting therapeutic target in case of predictable AKI (e.g. partial nephrectomy or renal transplantation). 30100067 2018
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 AlteredExpression disease BEFREE PA had potential therapeutic effects on sepsis-induced AKI in rats, and the activity may be associated with the anti-inflammatory function and antioxidant effect via activating Nrf2/ HO-1 pathway. 28485784 2017
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE This review highlights recent advances in the molecular mechanisms of HO-1-mediated cytoprotection and discusses the translational potential of HO-1 induction in AKI. 28139396 2017
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE We did not find an association between the GT(n) tandem repeat of HO-1 and AKI nor BPD/mortality. 25751573 2015
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE Thus, these bacterial artificial chromosome humanized HO-1 mice are a valuable model to study the human HO-1 gene, providing insight to the in vivo architecture of the gene in acute kidney injury and other diseases. 22495295 2012
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Therapeutic disease CTD_human In addition, conditioned medium of HO-1+/+ MSC rescued functional and morphological changes associated with cisplatin-induced AKI, while the HO-1-/--conditioned medium was ineffectual. 21048024 2011
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 Biomarker disease BEFREE In this review, recent findings concerning the role of HO-1 as a protective response against oxidative stress conditions are summarized, with a particular emphasis on its protective role in ischemic acute renal failure. 11928711 2002
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.400 AlteredExpression disease BEFREE These studies provide a basis for future studies using targeted gene expression of HO-1 as a therapeutic and preventive modality in high-risk settings of acute renal failure. 10807584 2000