Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bilirubin levels may become elevated as a result of heme oxygenase-1 activation, occurring in exercise-induced acute kidney injury in patients with RHUC; this phenomenon suggests renal ischemia-reperfusion injury.
|
31771519 |
2019 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lowering Hcy level or HO-1 induction might be a potential therapeutic strategy to improve the outcome of AKI.
|
30084650 |
2019 |
Kidney Failure, Acute
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 300 patients with severe AKI (KDIGO 2 or 3) and 353 controls without AKI (KDIGO 0) for the guanine-thymine (GTn) repeat in the promoter region of the HMOX1 gene.
|
31120979 |
2019 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the use of hemin-induced HO-1 to prevent AKI-induced ALI remains poorly investigated.
|
31530210 |
2019 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the PDK4 and HO-1 gene expression only increased in the ISS group on day 4 post-AKI.
|
31001374 |
2019 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
6-Shogaol protects against ischemic acute kidney injury by modulating NF-κB and heme oxygenase-1 pathways.
|
31313953 |
2019 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, we documented that TLR2 plays a protective role in cisplatin-induced AKI progression, in part, by a mechanism associated with autophagy up-regulation, considering that its interplay with HO-1 can promote renal tissue recover.
|
29500224 |
2018 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective against AKI because of its antiapoptotic and anti-inflammatory properties.
|
28515173 |
2018 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, HO-1 might be an interesting therapeutic target in case of predictable AKI (e.g. partial nephrectomy or renal transplantation).
|
30100067 |
2018 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PA had potential therapeutic effects on sepsis-induced AKI in rats, and the activity may be associated with the anti-inflammatory function and antioxidant effect via activating Nrf2/ HO-1 pathway.
|
28485784 |
2017 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review highlights recent advances in the molecular mechanisms of HO-1-mediated cytoprotection and discusses the translational potential of HO-1 induction in AKI.
|
28139396 |
2017 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
We did not find an association between the GT(n) tandem repeat of HO-1 and AKI nor BPD/mortality.
|
25751573 |
2015 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, these bacterial artificial chromosome humanized HO-1 mice are a valuable model to study the human HO-1 gene, providing insight to the in vivo architecture of the gene in acute kidney injury and other diseases.
|
22495295 |
2012 |
Kidney Failure, Acute
|
0.400 |
Therapeutic
|
disease |
CTD_human |
In addition, conditioned medium of HO-1+/+ MSC rescued functional and morphological changes associated with cisplatin-induced AKI, while the HO-1-/--conditioned medium was ineffectual.
|
21048024 |
2011 |
Kidney Failure, Acute
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review, recent findings concerning the role of HO-1 as a protective response against oxidative stress conditions are summarized, with a particular emphasis on its protective role in ischemic acute renal failure.
|
11928711 |
2002 |
Kidney Failure, Acute
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These studies provide a basis for future studies using targeted gene expression of HO-1 as a therapeutic and preventive modality in high-risk settings of acute renal failure.
|
10807584 |
2000 |