Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggested that HO-1 was able to increase prostate carcinoma cell invasion in vitro and tumor growth in vivo.
|
31810001 |
2020 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We did not observe HO-1 staining in tumor cells, but high HO-1 reactivity was detected in tumor infiltrating macrophages.
|
30813528 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results demonstrated that Nrf2, NQO1 and HO-1 were significantly upregulated in RCC tissues compared with adjacent tissues and were associated with tumor node metastasis stage, Fuhrman classification and lymph node metastasis.
|
31186733 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As one of antioxidant defense systems, heme oxygenase-1 (HO-1) acts as an essential role in tumor development by offering antioxidant bilirubin to protect cancer cells under stress conditions.
|
30605610 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The weight and survival rate of tumor mice were associated with HO-1 expression.
|
30368867 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long-term effects of HO-1 induction included increased CD8<sup>+</sup> T cell infiltration as well as delayed and reduced tumour growth in one-year-old animals.
|
30389969 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have shown that HO-1 is overexpressed in thyroid cancer and is associated with tumor aggressiveness.
|
30149527 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we show that TGFβ also promotes genomic instability in the form of DNA double strand breaks (DSB) in cancer cells that lack the tumor suppressor gene <i>RUNX3</i> Loss of RUNX3 resulted in transcriptional downregulation of the redox regulator heme oxygenase-1 (HO-1 or HMOX1).
|
29074538 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin.
|
29311669 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that sorafenib attenuates DHA-induced HO-1 expression and acts in synergy with DHA to suppress cancer cell viability and tumor growth.
|
30367621 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness.
|
28846111 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, silencing HO-1 gene expression enhanced vorinostat-induced tumor cell apoptosis, prolonged survival time and promoted P27<sup>Kip1</sup> protein expression in a xenograft mouse model.
|
29108243 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNA-1304 is a tumor suppressor and HO-1 is its direct target in NSCLC.
|
27641735 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
KSHV infection of endothelial cells (EC) <i>in vitro</i> increases expression of the inducible host-encoded enzyme heme oxygenase-1 (HO-1), which is also strongly expressed in KS tumors.
|
28421060 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overall, these findings identify the dual inhibition of HO-1 by miR-1254 as a novel functional mechanism of miRNA, which results in a more effective inhibition of oncogenic mRNA, and leads to a tumor suppressive effect.
|
28749936 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nevertheless, several lines of evidence have highlighted the role of HO-1 in cancer progression and its expression correlates with tumor growth, aggressiveness, metastatic and angiogenetic potential, resistance to therapy, tumor escape, and poor prognosis, even though a tumor- and tissue-specific activity has been observed.
|
28475131 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To gain clinical insight, we used prostate cancer patient-derived samples in our studies to assess the expression of HO-1 and other relevant genes.<b>Results:</b> Conditioning resulted in increased tumor latency and decreased initial growth rate.
|
28512172 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA level of Hmox1 in the tumor tissue of CRC is not correlated with that of the Nrf2 pathway molecules, and its ratio to the Nrf2 level may be useful for suggesting distant metastasis in CRC.
|
27999449 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, immunohistochemical analysis of 31 tumor tissues from DLBCL patients [20 of ABC subtype and 11 of germinal center B-cell-like (GCB) subtype] and 11 normal lymph nodes revealed that HO-1 overexpression was characteristic of ABC-DLBCL.
|
27211510 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have previously identified that heme oxygenase-1 (HO-1, encoded by HMOX1) inhibits MEC tumor growth and modulates the transcriptome of microRNAs.
|
26393425 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Growing evidence indicates that heme oxygenase-1 (HO-1) is up-regulated in malignancies and subsequently alters tumor aggressiveness and various cancer-related factors, such as high glucose (HG) levels.
|
25661467 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It has been shown that HO-1 is susceptible to proteolytic cleavage and translocates to nucleus to facilitate tumor growth and invasion independent of its enzymatic activity.
|
25885228 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we investigated whether expression of the metabolic gene, heme oxygenase-1 (HO-1) in tumor microenvironment imparts significant effects on prostate cancer progression.We showed that HO-1 is expressed in MARCO-positive macrophages in prostate cancer (PCa) xenografts and human prostate cancers.
|
26418896 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Heme oxygenase-1 (HO)-1 is known to be involved in the development and progression of tumors.
|
25876647 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hence, the results support the anti-apoptotic role of HO-1 induced by NHE1 in the K562R cell line and IM-insensitive CML patients and provide a mechanism by which inducing HO-1 expression via the PKC-β/p38-MAPK pathway may promote tumor resistance to oxidative stress.
|
25802333 |
2015 |