|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heme oxygenase-1 (HO-1) is an important anti-inflammatory heat shock protein and plays a similar effect on sepsis.
|
30605726 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we evaluate the effect of microRNA-31 (miR-31) on intestinal barrier dysfunction through NF-κB/HIF-1α pathway by targeting HMOX1 in rats with sepsis.
|
30340459 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of CRBN in macrophage of KO mice suppressed activation of 5' adenosine monophosphate-activated protein kinase (AMPK) and HO-1 and augmented expression of TNF-α and HMGB1 as inhibition of AMPK by compound C. These studies demonstrate the contribution of CRBN expression to the pathogenesis of CLP-induced sepsis and peritoneal macrophage responses and suggest a novel therapeutic modality for polymicrobial sepsis.
|
29170136 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mechanism underlying the protective effect of acacetin on sepsis is related to the regulation of certain antioxidation genes, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), superoxide dismutases (SODs), and heme oxygenase 1 (HO-1).Taken together, our results indicate that acacetin pre-treatment inhibits sepsis-induced ALI through its anti-inflammatory and antioxidative activity, suggesting that acacetin may be a potential protective agent for sepsis-induced ALI.
|
29243040 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A partial deficiency in HO-1 increased the progression and mortality in sepsis.
|
29795214 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the role of HO-1 activation in the development of endoplasmic reticulum (ER) stress during sepsis remains unknown.
|
30013453 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Long-term treatment with raloxifene reduces the severity of sepsis in OVX rats, attributed from up-regulation of HSP70 and HO-1 to exert the antioxidant and anti-inflammatory capacities.
|
28350760 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Besides its effects on cell metabolism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to sepsis, transplantation, and autoimmunity, and preventing oxidative damage associated with inflammation.
|
28082120 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore investigated the immunosuppressive role of HO-1 in sepsis with a focus on its effects on helper T-cell (Th) differentiation and regulatory T cells (Treg).
|
28368519 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since HO-1 is developmentally regulated, it may play a role in the pathogenesis of preterm sepsis.
|
27454382 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Next, the role of Nrf2/HO-1 was investigated in activated HUVECs, as well as in wild-type and Nrf(-/-) mice with sepsis.
|
26253656 |
2015 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
NF-E2-related factor 2 (Nrf2) has been demonstrated to be a key transcription factor regulating the anti-inflammatory genes including heme oxygenase-1 (HO-1) in experimental sepsis models.
|
24474616 |
2014 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Heme oxygenase-1 (HMOX1) is a stress protein with a polymorphic (GT)n repeat in its gene promoter that regulates its expression in response to oxidative injury, such as that present in sepsis.
|
24201221 |
2013 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The immune modulatory effect of heme oxygenase-1 (HO-1) is well documented in studies about sepsis and transplantation.
|
23521418 |
2013 |
|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested whether a highly polymorphic (GT)n microsatellite and single-nucleotide polymorphisms in HMOX1 and BLVRA/B genes are associated with outcome of sepsis.
|
23042203 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction.
|
21083424 |
2011 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The induction of heme oxygenase-1 (HO-1; Hmox1) by inflammation, for instance in sepsis, is associated both with an anti-inflammatory response and with mitochondrial biogenesis.
|
21454555 |
2011 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, injection of a CO-releasing molecule into WT mice increased phagocytosis and rescued HO-1-deficient mice from sepsis-induced lethality.
|
18060048 |
2008 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results show for the first time that LPS induces NQO1 and HO-1 expression in human monocytes via Nrf2 to modulate their inflammatory responsiveness, thus providing novel potential therapeutic strategies for the treatment of sepsis.
|
18981090 |
2008 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The increase in heme oxygenase-1 expression may add to the understanding of the increase in serum bilirubin observed in patients with SIRS/sepsis.
|
15530192 |
2004 |