FOXA2, forkhead box A2, 3170

N. diseases: 143; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235833
Disease: Congenital diaphragmatic hernia
Congenital diaphragmatic hernia 		0.010 AlteredExpression disease BEFREE Meanwhile, we also showed that miR-130a-5p was significantly upregulated in CDH lungs and thus inversely correlated with Foxa2. 31843527 2020
CUI: C0265783
Disease: Congenital hypoplasia of lung
Congenital hypoplasia of lung 		0.010 Biomarker disease BEFREE This study was the first to show that the miR-130a-5p/Foxa2 axis played a crucial role in CDH-associated pulmonary hypoplasia. 31843527 2020
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.010 Biomarker group BEFREE Our current study indicated that both single bacterial infection by Pseudomonas aeruginosa and Bordetella bronchiseptica and polymicrobial infection by viral/bacterial pathogens depleted FOXA2 in canine airways, resulting in goblet cell hyperplasia and metaplasia and excessive mucus production. 30221439 2019
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.010 Biomarker group BEFREE Members of the forkhead-box A (FOXA) family, including FOXA1 and FOXA2, have been reported to regulate EC progression. 30944629 2019
CUI: C0019202
Disease: Hepatolenticular Degeneration
Hepatolenticular Degeneration 		0.010 AlteredExpression disease BEFREE Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha (HNF4A), Retinoid X Receptor alpha (RXRA), Forkhead Box A1 (FOXA1), and FOXA2. 30709419 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.010 AlteredExpression disease BEFREE Following intervention with adiponectin in obese mice, blood glucose, insulin and HOMA-IR were significantly decreased, whilst plasma adiponectin, ApoM mRNA expression, Foxa2 mRNA expression and ApoM protein were all significantly increased. 31410126 2019
CUI: C0035204
Disease: Respiration Disorders
Respiration Disorders 		0.010 Biomarker group BEFREE FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases. 30221439 2019
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.010 Biomarker disease BEFREE Members of the forkhead-box A (FOXA) family, including FOXA1 and FOXA2, have been reported to regulate EC progression. 30944629 2019
CUI: C0158986
Disease: Neonatal hypoglycemia
Neonatal hypoglycemia 		0.010 Biomarker disease BEFREE We suggest to include FOXA2 analysis for neonatal hypoglycemia and to implement a long-term follow-up, particularly for the risk of diabetes. 30684292 2019
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma 		0.010 Biomarker disease BEFREE Opposing Roles of the Forkhead Box Factors FoxM1 and FoxA2 in Liver Cancer. 30814128 2019
CUI: C0275524
Disease: Coinfection
Coinfection 		0.010 Biomarker phenotype BEFREE Our current study indicated that both single bacterial infection by Pseudomonas aeruginosa and Bordetella bronchiseptica and polymicrobial infection by viral/bacterial pathogens depleted FOXA2 in canine airways, resulting in goblet cell hyperplasia and metaplasia and excessive mucus production. 30221439 2019
CUI: C0276447
Disease: Rhinovirus infection
Rhinovirus infection 		0.010 AlteredExpression disease BEFREE Importantly, infection of epithelial cells with human rhinovirus similarly reduced expression of these two genes, which suggests that FOXA2 may be the common regulator of SCGB1A1. 30576223 2019
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.010 Biomarker disease BEFREE Opposing Roles of the Forkhead Box Factors FoxM1 and FoxA2 in Liver Cancer. 30814128 2019
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.010 Biomarker disease BEFREE Opposing Roles of the Forkhead Box Factors FoxM1 and FoxA2 in Liver Cancer. 30814128 2019
CUI: C0345905
Disease: Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma 		0.010 AlteredExpression disease BEFREE Low FOXA2 expression negatively affected the prognosis of patients with ICC. 31689237 2019
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.010 Biomarker disease BEFREE Members of the forkhead-box A (FOXA) family, including FOXA1 and FOXA2, have been reported to regulate EC progression. 30944629 2019
CUI: C0687140
Disease: Hemangioma of skin
Hemangioma of skin 		0.010 AlteredExpression disease BEFREE Overexpression of the Hedgehog signaling components SHH and GLI2 and its target gene FOXA2 in HH were similar to those found in aggressive skin hemangioma and KHE, their expression being significantly higher than in mild skin hemangioma. 31092427 2019
CUI: C1112213
Disease: Cholestasis in newborn
Cholestasis in newborn 		0.010 Biomarker disease BEFREE A strong significant statistical difference between BA and NC group (P<0.0001) with regard to Hnf1β and FoxA2 immunoexpression was evident. 29406331 2019
CUI: C1302790
Disease: Congenital malformation syndrome
Congenital malformation syndrome 		0.010 GeneticVariation disease BEFREE A defect in the FOXA2 DNA-binding domain was associated with childhood-onset diabetes and multiple congenital anomalies, which reflected the pleiotropic nature of the gene. 30684292 2019
CUI: C1367420
Disease: Kaposiform Hemangioendothelioma
Kaposiform Hemangioendothelioma 		0.010 AlteredExpression disease BEFREE Overexpression of the Hedgehog signaling components SHH and GLI2 and its target gene FOXA2 in HH were similar to those found in aggressive skin hemangioma and KHE, their expression being significantly higher than in mild skin hemangioma. 31092427 2019
CUI: C1535939
Disease: Pneumocystis jiroveci pneumonia
Pneumocystis jiroveci pneumonia 		0.010 AlteredExpression disease BEFREE We measured MUC5B and Pneumocystis in infant lungs, and progression of mucin levels and effect of inhibition of the STAT6/FoxA2 mucus pathway using Kaempferol, a JAK/STAT6 inhibitor, in immunocompetent rats during Pneumocystis primary infection. 30765827 2019
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 AlteredExpression disease BEFREE <b>Results:</b> HNF3β expression was lower in colon cancer tissue compared to normal tissue and correlated with UICC clinical stage (<i>P</i> = 0.001), depth of invasion (<i>P</i> = 0.004), regional lymph node metastasis (<i>P</i> = 0.007), distant metastasis (<i>P</i> = 0.048), and poor survival (<i>P</i> < 0.001) in patients with colorectal cancer. 31696055 2019
CUI: C0002726
Disease: Amyloidosis
Amyloidosis 		0.010 AlteredExpression disease BEFREE This study suggests a novel regulatory pathway in β-cells involving proteasome, FOXA2, and <i>IAPP</i>, which can be possibly targeted to regulate hIAPP levels and islet amyloidosis in T2DM. 30012886 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.010 AlteredExpression group BEFREE Thus, Foxa1 and Foxa2 in TEC promote positive selection of CD4SP T-cells and modulate regulatory T-cell production and activity, of importance to autoimmunity. 30061015 2018
CUI: C0007140
Disease: Carcinosarcoma
Carcinosarcoma 		0.010 AlteredExpression disease BEFREE The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas. 28940304 2018