|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Kaplan-Meier was used to explore the relationship among the expressions of miR-942 and FOXA2 and the prognosis of BCa patients.
|
31701999 |
2019 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that PGC-1β was upregulated and FOXA2 was downregulated in breast cancer tissues and cell lines.
|
31007610 |
2019 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our purpose was to analyze the expression of FOXA2 in breast cancer cells, to explore its role in breast cancer stem cells, and to correlate its mRNA expression with clinicopathological features and outcome in a series of patients diagnosed with breast carcinoma.
|
26298189 |
2015 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes.
|
27045898 |
2016 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this study, we found that FOXA2 prevented the epithelial to mesenchymal transition (EMT) in human breast cancer.
|
25779673 |
2015 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis.
|
27322206 |
2016 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we show that IKKα, an important downstream kinase of TNFα, interacts with and phosphorylates FOXA2 at S107/S111, thereby suppressing FOXA2 transactivation activity and leading to decreased NUMB expression, and further activates the downstream NOTCH pathway and promotes cell proliferation and tumorigenesis.
|
22196886 |
2012 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Forkhead box protein A2 (FOXA2) plays an important in development, cellular metabolism and tumorigenesis.
|
27538367 |
2016 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
We have identified FOXA2 as a novel tumor suppressor in pancreatic cancer and it is regulated directly by miR-199a, thereby enhancing our understanding of how microRNAs interplay with the transcription factors to affect pancreatic oncogenesis.
|
27151939 |
2016 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these results show that FOXA2 may play an important role in proliferation, invasion, and tumorigenesis in glioma cells.
|
27983925 |
2017 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Infection of BGC-823 cells by FOXA2 lentivirus resulted in reduced cell tumorigenesis in vitro and in vivo.
|
25129104 |
2015 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
The functional diversification of the FOXA1 and FOXA2 contributes to the target genes during evolution and carcinogenesis.
|
26658322 |
2015 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Decreased expression of FOXA2 inhibited tumorigenesis of colon cancer cells in nude mice.
|
29896233 |
2018 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas.
|
28940304 |
2018 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Putative prostate tumor stem cells that express BCRP but not AR protein in TRAMP are the source of a BCRP-negative and AR-negative, Foxa2- and SV40Tag-expressing, transit amplifying compartment that progresses to the poorly differentiated carcinomas that arise rapidly after castration.
|
16061644 |
2005 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Studies also implicate FOXA2 in bladder cancer and several other FOX proteins might be involved in development and/or progression of this disease; for example, FOXA1 and FOXO3A have been associated with clinical patient outcomes.
|
27898096 |
2017 |
|
Carcinoma of lung
|
0.070 |
Biomarker
|
disease |
BEFREE |
Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2, and their genetic interaction is associated with lung cancer.
|
25667220 |
2015 |
|
Carcinoma of lung
|
0.070 |
Biomarker
|
disease |
BEFREE |
The present study showed that in human lung cancer cell lines, the abundance of FOXA2 positively correlates with epithelial phenotypes and negatively correlates with the mesenchymal phenotypes of cells, and TGF-β1 treatment decreased FOXA2 protein level.
|
20820189 |
2011 |
|
Carcinoma of lung
|
0.070 |
Biomarker
|
disease |
BEFREE |
Furthermore, the LinkedOmics database was used to evaluate the prognostic values, indicating that higher expression of FOXA1, FOXA3 indicated a poor overall survival (OS), while increased FOXA2 revealed a better OS in lung cancer.
|
30415009 |
2019 |
|
Carcinoma of lung
|
0.070 |
Biomarker
|
disease |
BEFREE |
A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.
|
15205324 |
2004 |
|
Carcinoma of lung
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
These results provide opportunities to understand the FOXA2-centered transcriptional regulation network and novel therapeutic targets to modulate this network in p53-deficient lung cancer.
|
26093302 |
2015 |
|
Carcinoma of lung
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
A series of 25 lung cancer cell lines were evaluated for Foxa2 protein expression, FOXA2 mRNA levels, FOXA2 mutations, FOXA2 copy number changes and for evidence of FOXA2 promoter hypermethylation.
|
22341411 |
2012 |
|
Carcinoma of lung
|
0.070 |
Biomarker
|
disease |
BEFREE |
Thus, NKX2-1, FoxA1 and FoxA2 coordinately regulate the growth and identity of lung cancer in a context-specific manner.
|
30475207 |
2018 |
|
Carcinoma, Neuroendocrine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prominent Foxa1 and Foxa2 expression was observed in 12T-10 invasive undifferentiated neuroendocrine carcinomas, in the hormone independent and metastasizing 12T-10 derived, NE-10 allograft tumors, and in all metastatic lesions isolated from 12T-10 mice.
|
16001449 |
2006 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
Autophagy and FOXA2 are therefore potential targets for ovarian cancer stem cell directed therapies.
|
29187221 |
2017 |