|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HNF‑4α downregulation promotes tumor migration and invasion by regulating E‑cadherin in renal cell carcinoma.
|
31322246 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activation of Wnt signaling through beta-catenin/TCF complexes is a key event in the development of various tumors, in particular colorectal and liver tumors.
|
11809809 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5.
|
23435428 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, immunohistochemistry demonstrated that HNF-4α was overexpressed in human GC tissues, and associated with tumor stage and lymph node metastasis.
|
29344114 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, nude mice administered MSC-HNF4α exhibited significantly smaller tumors compared with controls in vivo.
|
27124543 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinically, HIC1 and HNF4A conversely correlate with tumor stage in liver cancer.
|
31108460 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our data indicate that TCF-4K functions as a tumor suppressor in NSCLC by down-regulating the Wnt pathway.
|
26535715 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we show that Hnf4α does not act as a tumor-suppressor gene but is crucial in promoting gut tumorigenesis in mice.
|
21062980 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High TCF activity Huh7 cells led to earlier and larger tumor formation when xenografted into nude mice.
|
20538055 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis of approximately 450 human colon cancer specimens (Stage III) reveals that P1-HNF4α is either lost or localized in the cytoplasm in approximately 80% of tumors, and that staining for active Src correlates with those events in a subset of samples.
|
22308320 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, P2-HNF4alpha was expressed in all tumors regardless of the mucin phenotype.
|
19563409 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signaling pathway.
|
29279096 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It also regulated crucial transcription factors viz. hepatocyte nuclear factor alpha (HNF4A) and tumor suppressor protein 53 (p53).
|
30414976 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Multiple sets of genes and molecular biological processes involved during HCC development were identified from this integrative analysis: (i) Loss of liver cellular features due to the reduced HNF4A & PPAR signaling in the early stages of HCC, (ii) activated inflammatory and stress signals in the cirrhosis stages and (iii) highly activated cellular proliferation with the activated E2F-MYC oncogenic signaling with the gain of embryonic liver stem cell-like features in the advanced stage tumors.
|
27194100 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mutational inactivation in the tumor suppressor adenomatous polyposis coli (APC), as well as activation of beta-catenin, causes the accumulation of beta-catenin, which in turn associates with the T cell factor/lymphoid enhancer factor (TCF/LEF) family of transcription factors and activates transcription of their target genes.
|
14660579 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Of these factors, HNF4A acts both as a master regulator of liver organogenesis and a tumor suppressor in the liver.
|
29899848 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, Tcf factors have been reported as tumor inducers, aberrantly activating their target genes as a result of elevated beta-catenin levels in many types of cancer.
|
10528152 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Stable DKK4-transfected cells were established, and DKK4 functional analyses were performed, including a T-cell factor/lymphoid enhancer factor (TCF/LEF) reporter assay, and experiments on cell viability, apoptosis, invasive capability and tumor growth in vivo.
|
24573574 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, these data demonstrate the efficacy of disrupting the beta-catenin/TCF transcriptional complex to exploit tumor dependence on Wnt signaling as a therapeutic approach in the treatment of MM.
|
17452641 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The abundance and activity of HNF4alpha are frequently reduced in renal cell carcinoma (RCC) indicating some tumor suppressing function of HNF4alpha in renal cells.
|
16007190 |
2005 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The effect of v-Src was abrogated by a dominant-negative mutant of TCF and the tumor suppressor APC.
|
14706618 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of E-cadherin, Fibronectin, N-cadherin, Vimentin, Hepatocyte nuclear factor 4alpha (HNF4alpha), Snail and Slug was assessed in primary tumors and their corresponding metastases by immunohistochemical staining.
|
24059685 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The induction of beta-catenin/TCF mediated transcription is both a frequent early event in colorectal neoplasia, and a key downstream effect of wnt growth factor signalling.
|
16523202 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The P1 and P2 promoter-driven HNF4alpha expression pattern of tumour metastases correlated with the primary site of origin.
|
16400631 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The protein expression of the tumor suppressor HNF4α may be inhibited by interactions of RBPs with the G4 motif in the 5' UTR to promote cell proliferation during liver development and carcinogenesis.
|
29234104 |
2017 |