HNF4A, hepatocyte nuclear factor 4 alpha, 3172

N. diseases: 340; N. variants: 74
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 AlteredExpression disease BEFREE Dysregulation of HNF4α expression has been associated with many human diseases such as ulcerative colitis, colon cancer, maturity-onset diabetes of the young, liver cirrhosis, and hepatocellular carcinoma. 31435165 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 Biomarker disease BEFREE At single-gene level, the associated barrier single-nucleotide polymorphisms were most significantly enriched in PTGER4 for CD and HNF4A for UC. 28885228 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 Biomarker disease BEFREE Recently, HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies. 24415854 2014
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 GeneticVariation disease BEFREE Moreover, in a genome-wide association study, the HNF4A locus has been associated with ulcerative colitis. 22914433 2012
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 Biomarker disease BEFREE Genetic evidence has also demonstrated the importance of barrier function to the development of ulcerative colitis (HNF4A, LAMB1, CDH1 and GNA12). 21300624 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 GeneticVariation disease BEFREE Our data suggest that FCGR2A, JAK2 or HNF4A variants play a role in the pathogenesis of ulcerative colitis in Koreans. 21831733 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 Biomarker disease CTD_human Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. 19915572 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.370 GeneticVariation disease BEFREE Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. 19915572 2009