In line with this notion, a nonsynonymous single nucleotide polymorphism within a highly conserved domain of HOXA1--rs10951154" genes_norm="3198">A218G (rs10951154)--has been linked to both ASD risk, and cross-sectional differences in superior posterior lobar cerebellar anatomy in late adulthood.
The rs10951154" genes_norm="3198">A218G (rs10951154) in HOXA1 and the insertion variant in HOXB1 (nINS/INS, rs72338773) were of special interest for ASD but with inconclusive results.
The results support a role for HOXA1 in susceptibility to autism, and add to the existing body of evidence implicating early brain stem injury in the etiology of ASDs.