|
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed the expression pattern of the entire HOX 1 locus in a panel of leukemia-derived human cell lines representing various blood phenotypes.
|
1348930 |
1992 |
|
Chronic Obstructive Airway Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in HOX-1 and mEPH genes are associated with the development of COPD in Southwest China.
|
17203192 |
2007 |
|
Chronic Obstructive Airway Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphism in HOX-1 is associated with the severity of COPD in Southwest China.
|
17254481 |
2007 |
|
Childhood Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have analyzed the expression pattern of the entire HOX 1 locus in a panel of leukemia-derived human cell lines representing various blood phenotypes.
|
1348930 |
1992 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival (P = .0104), which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization.
|
17959889 |
2007 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice.
|
29455183 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Taken together, these results demonstrated the tumor suppressive role of miR-144-3p in NB and may advance the understanding of the underlying mechanisms of miR-144-3p and HOXA7 in NB.
|
30720179 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
Biomarker
|
disease |
BEFREE |
The study suggested that HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia, and provided the molecular basis for the treatment for acute promyelocyticleukemia.
|
26828989 |
2016 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
Biomarker
|
disease |
BEFREE |
MEIS1 and HOXA7 genes in human acute myeloid leukemia.
|
10996203 |
2000 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
Biomarker
|
disease |
BEFREE |
Coexpression of the homeodomain protein Meis1 and either HoxA7 or HoxA9 is characteristic of many acute myelogenous leukemias.
|
15479723 |
2005 |
|
ovarian neoplasm
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings associate aberrant HOXA7 expression with the müllerian-like differentiation of epithelial ovarian tumors and suggest diagnostic utility of serum antibodies to HOXA7.
|
11742062 |
2001 |
|
ovarian neoplasm
|
0.030 |
Biomarker
|
disease |
BEFREE |
Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice.
|
29455183 |
2018 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate a novel mechanistic role for HOXA7 in modulating breast cancer cell proliferation via regulation of ERα expression.
|
24099775 |
2013 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In this report, we revealed that HOXA7 promoted metastasis of HCC patients.
|
27600149 |
2016 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate a novel mechanistic role for HOXA7 in modulating breast cancer cell proliferation via regulation of ERα expression.
|
24099775 |
2013 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Moreover, HOXA7-siRNA inhibited migration and invasion in vitro, and downregulated MMP9 at the protein level in U251 glioma cells.
|
27677590 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features.
|
17959889 |
2007 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
There were significant associations of strong HOXA7 staining of stroma and tumor nuclei with the clear cell histotype (stroma: P = .0022, nuclei: P = .0003) and of weak/absent staining with serous carcinomas.
|
17959889 |
2007 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD133 (p = 0.021) and HOXA7 (p = 0.001) were independent prognostic markers when the three glioma patient cohorts were combined (n = 231).
|
28055976 |
2017 |
|
granulosa cell tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
We generated a thoroughly characterized polyclonal rabbit antibody against human HOXA7 and used it to study the distribution, role, and regulation of HOXA7 in human ovarian folliculogenesis and in granulosa cell tumors.
|
16466395 |
2006 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrated the tumor suppressive role of miR-144-3p in NB and may advance the understanding of the underlying mechanisms of miR-144-3p and HOXA7 in NB.
|
30720179 |
2019 |
|
Werner Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gene expression changes that were common to all three cell types included up-regulation of GCK (glucokinase), CS (citrate synthase), HOX1 (heme oxygenase 1), CKMT2 (mitochondrial creatine kinase 2), MYC (v-myc myelocytomatosis viral oncogene homolog), and WRN (Werner syndrome helicase), and down-regulation of FBP1 (fructose-1, 6-bisphosphatase 1) and COL4A1 (collagen, type IV, alpha 1).
|
15561107 |
2005 |
|
Meningiomas, Multiple
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, in newly diagnosed WHO I meningiomas, HOXA7, 9, and 10 methylation was significantly lower than in WHO I samples derived from recurring tumors, and multiple meningiomas presented significantly higher HOXA 10 methylation with respect to solitary meningiomas.
|
22735029 |
2012 |
|
Chromosome 9, trisomy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of four homeobox transcripts (HoxA7, HoxB4+ ++, HoxB5, and HoxC6) that are expressed in diploid embryos, only HoxA7, HoxB4 and HoxC6 were present in a trisomy 7 embryo, and only HoxB4 and HoxB 5 in triploid embryos and an embryo with trisomy 9.
|
8688592 |
1996 |
|
Leukemogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the current study, we identified Hoxa7, Hoxa9 and Hox cofactor Meis1 as AP-2α target genes, which are involved in myeloid leukemogenesis.
|
23660297 |
2013 |